Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GALR2 | O43603 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1573971 | 0.85 | MAP2K4 (0.42) | ALDH1A1SMN1; SMN2LRRK2NTRK1MAPK1 | |
| SCHEMBL1574048 | 0.85 | GRM4 (0.41) | ALDH1A1SMN1; SMN2NTRK1MAPK1MAP2K4 | |
| SCHEMBL1573854 | 0.79 | RBP4 (0.45) | MAPK1MAP2K4 | |
| SCHEMBL1573919 | 0.79 | HRH4 (0.47) | ALDH1A1MAPK1MAP2K4 | |
| SCHEMBL1573862 | 0.79 | ALDH1A1 (0.44) | ALDH1A1LMNAMAPTSMN1; SMN2HTT | |
| SCHEMBL1573835 | 0.77 | GAA (0.45) | ALDH1A1SMN1; SMN2KDM4EMAPK1MAP2K4 | |
| SCHEMBL1573920 | 0.77 | MAP2K4 (0.41) | ALDH1A1LMNAMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL1573781 | 0.77 | MAP2K4 (0.41) | ALDH1A1MAPK1MAP2K4 | |
| SCHEMBL1574198 | 0.77 | TP53 (0.47) | SMN1; SMN2MAPK1MAP2K4CYP1A2CYP2C19 | |
| SCHEMBL1574118 | 0.75 | FLT3 (0.47) | SMN1; SMN2MAPK1MEN1KMT2ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713779-B1 | INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE-SENSITIVE LIPASES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-04-13 | — | — | EP | disclosed |