Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Paquinimod SCHEMBL1573633 | 0.99 | MEN1 (0.50) | MEN1KMT2APGRHDAC4ALDH1A1 | |
| Paquinimod SCHEMBL29362498 | 0.99 | MEN1 (0.50) | MEN1KMT2APGRHDAC4ALDH1A1 | |
| Paquinimod SCHEMBL1573462 | 0.98 | MEN1 (0.49) | MEN1KMT2APGRHDAC4ALDH1A1 | |
| Paquinimod SCHEMBL1573731 | 0.98 | MEN1 (0.49) | MEN1KMT2APGRHDAC4ALDH1A1 | |
| Paquinimod SCHEMBL1573460 | 0.98 | MEN1 (0.49) | MEN1KMT2APGRHDAC4ALDH1A1 | |
| SCHEMBL8144316 | 0.91 | MEN1 (0.47) | MEN1KMT2APGRHDAC4ALDH1A1 | |
| SCHEMBL19628902 | 0.90 | MEN1 (0.48) | MEN1KMT2APGRHDAC4ALDH1A1 | |
| SCHEMBL7537716 | 0.89 | HDAC4 (0.43) | MEN1KMT2APGRHDAC4ALDH1A1 | |
| SCHEMBL15190559 | 0.89 | MEN1 (0.51) | MEN1KMT2APGRHDAC4ALDH1A1 | |
| SCHEMBL5164257 | 0.88 | MEN1 (0.50) | MEN1KMT2APGRHDAC4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8754104-B2 | Crystalline salts of quinoline compounds and methods for preparing them | ACTIVE BIOTECH AB (SE) | 2014-06-17 | — | — | US | disclosed |
| US-20130123301-A1 | CRYSTALLINE SALTS OF QUINOLINE COMPOUNDS AND METHODS FOR PREPARING THEM | ACTIVE BIOTECH AB (SE) | 2013-05-16 | — | — | US | disclosed |
| US-8314124-B2 | Crystalline salts of quinoline compounds and methods for preparing them | ACTIVE BIOTECH AB (SE) | 2012-11-20 | — | — | US | disclosed |
| EP-1720531-B1 | NEW COMPOSITIONS CONTAINING QUINOLINE COMPOUNDS | ACTIVE BIOTECH AB (SE) | 2011-04-13 | — | — | EP | disclosed |
| US-20090232889-A1 | CRYSTALLINE SALTS OF QUINOLINE COMPOUNDS AND METHODS FOR PREPARING THEM | ACTIVE BIOTECH AB (SE) | 2009-09-17 | — | — | US | disclosed |
| US-7589208-B2 | Solid dosage of a salt of a 3-quinoline-carboxamide derivative that is storage stable for three years; e.g. lithium or calcium salt of laquinimod | ACTIVE BIOTECH AB (SE) | 2009-09-15 | — | — | US | disclosed |
| US-20050192315-A1 | New compositions containing quinoline compounds | ACTIVE BIOTECH AB (SE) | 2005-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050192315-A1 | New compositions containing quinoline compounds | KCNQ2, SCN7A, KCNQ1 | MEN1 454/4885KMT2A 424/4885PGR 4289/4885 |
| US-20090232889-A1 | CRYSTALLINE SALTS OF QUINOLINE COMPOUNDS AND METHODS FOR PREPARING THEM | CA2, RECQL, CA7 | MEN1 605/4885KMT2A 1475/4885PGR 4549/4885 |
| US-20130123301-A1 | CRYSTALLINE SALTS OF QUINOLINE COMPOUNDS AND METHODS FOR PREPARING THEM | CA2, CA7, RECQL | MEN1 629/4885KMT2A 1472/4885PGR 4539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.