Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 2/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 7/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1573854 | 0.90 | RBP4 (0.45) | RBP4MAP2K4MAPK1MAPK6ABL1 | |
| SCHEMBL1573835 | 0.88 | GAA (0.45) | RBP4MAP2K4MAPK1MAPK6NPC1 | |
| SCHEMBL1573746 | 0.87 | RBP4 (0.48) | RBP4MAP2K4MAPK1MAPK6ABL1 | |
| SCHEMBL1573862 | 0.85 | ALDH1A1 (0.44) | RBP4MAP2K4MAPK1MAPK6RAB9A | |
| SCHEMBL1574209 | 0.84 | HRH3 (0.46) | RBP4MAP2K4MAPK1MAPK6ABL1 | |
| SCHEMBL1573681 | 0.84 | RBP4 (0.43) | RBP4MAP2K4MAPK1MAPK6ABL1 | |
| SCHEMBL1573930 | 0.84 | SMN1; SMN2 (0.47) | RBP4MAPK1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1573781 | 0.83 | MAP2K4 (0.41) | RBP4MAP2K4MAPK1MAPK6ABL1 | |
| SCHEMBL1573919 | 0.83 | HRH4 (0.47) | MAP2K4MAPK1MAPK6ABL1BCR | |
| SCHEMBL1574198 | 0.83 | TP53 (0.47) | MAP2K4MAPK1MAPK6SMN1; SMN2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713779-B1 | INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE-SENSITIVE LIPASES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-04-13 | — | — | EP | disclosed |
| CN-1914180-A | Indazole derivatives as hormone sensitive lipase inhibitors | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-02-14 | — | — | CN | disclosed |