Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 11/20 | 0.56 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.44 |
| ▸ | IKBKE | Q14164 | 4/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15737764 | 0.88 | TBK1 (0.65) | TBK1CSNK2A2CSNK2A1NOX1TRPV1 | |
| SCHEMBL15737174 | 0.87 | TBK1 (0.66) | TBK1CSNK2A2CSNK2A1NOX1TRPV1 | |
| SCHEMBL15737873 | 0.81 | TBK1 (0.58) | TBK1CSNK2A2CSNK2A1IKBKEPRKACA | |
| SCHEMBL14059709 | 0.79 | TBK1 (0.87) | TBK1IKBKE | |
| SCHEMBL15736317 | 0.79 | TBK1 (0.61) | TBK1CSNK2A2CSNK2A1IKBKEPRKACA | |
| SCHEMBL15737437 | 0.78 | TBK1 (0.79) | TBK1IKBKE | |
| SCHEMBL15738750 | 0.76 | TBK1 (0.63) | TBK1CSNK2A2CSNK2A1IKBKE | |
| SCHEMBL15737242 | 0.76 | IKBKE (0.59) | TBK1CSNK2A2CSNK2A1IKBKEPRKACA | |
| SCHEMBL15738653 | 0.74 | TBK1 (0.64) | TBK1CSNK2A2CSNK2A1NOX1PRKACA | |
| SCHEMBL15738283 | 0.74 | TBK1 (0.57) | TBK1CSNK2A2CSNK2A1IKBKEPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249114-B2 | Thiazole derivatives | MERCK PATENT GMBH (DE) | 2016-02-02 | — | — | US | claimed |
| US-20140148457-A1 | Thiazole derivatives | MERCK PATENT GMBH (DE) | 2014-05-29 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140148457-A1 | Thiazole derivatives | TBK1, IRAK1, IRF3 | TBK1 1/4885CSNK2A2 179/4885CSNK2A1 138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.