Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.58 |
| ▸ | IKBKE | Q14164 | 5/20 | 0.58 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.55 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15737242 | 0.84 | IKBKE (0.59) | TBK1IKBKECSNK2A2CSNK2A1MAPT | |
| SCHEMBL15736317 | 0.82 | TBK1 (0.61) | TBK1IKBKECSNK2A2CSNK2A1SMN1; SMN2 | |
| SCHEMBL15738283 | 0.82 | TBK1 (0.57) | TBK1IKBKECSNK2A2CSNK2A1SMN1; SMN2 | |
| SCHEMBL15738604 | 0.81 | TBK1 (0.56) | TBK1IKBKECSNK2A2CSNK2A1PRKACA | |
| SCHEMBL15738606 | 0.81 | TBK1 (0.60) | TBK1IKBKECSNK2A2CSNK2A1SMN1; SMN2 | |
| SCHEMBL15738750 | 0.79 | TBK1 (0.63) | TBK1IKBKECSNK2A2CSNK2A1 | |
| SCHEMBL15736046 | 0.78 | TBK1 (0.63) | TBK1IKBKECSNK2A2CSNK2A1POLB | |
| SCHEMBL15738653 | 0.77 | TBK1 (0.64) | TBK1CSNK2A2CSNK2A1PRKACAROCK1 | |
| SCHEMBL15737508 | 0.77 | TBK1 (0.58) | TBK1IKBKECSNK2A2CSNK2A1PRKACA | |
| SCHEMBL14059702 | 0.77 | TBK1 (0.65) | TBK1IKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249114-B2 | Thiazole derivatives | MERCK PATENT GMBH (DE) | 2016-02-02 | — | — | US | claimed |
| US-20140148457-A1 | Thiazole derivatives | MERCK PATENT GMBH (DE) | 2014-05-29 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140148457-A1 | Thiazole derivatives | TBK1, IRAK1, IRF3 | TBK1 1/4885IKBKE 17/4885CSNK2A2 179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.