Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 11/20 | 0.66 |
| ▸ | IKBKE | Q14164 | 6/20 | 0.66 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | LSS | P48449 | 2/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14059702 | 0.90 | TBK1 (0.65) | TBK1IKBKEKITFLT3 | |
| SCHEMBL15738750 | 0.89 | TBK1 (0.63) | TBK1IKBKEHRH3KITFLT3 | |
| SCHEMBL15737383 | 0.86 | TBK1 (0.65) | TBK1IKBKEKITFLT3HIF1A | |
| SCHEMBL15737742 | 0.86 | TBK1 (0.65) | TBK1IKBKEHIF1AEPAS1 | |
| SCHEMBL15736400 | 0.80 | TBK1 (0.85) | TBK1IKBKE | |
| SCHEMBL15736046 | 0.80 | TBK1 (0.63) | TBK1IKBKEKITFLT3CSNK2A2 | |
| SCHEMBL14059510 | 0.79 | TBK1 (1.00) | TBK1IKBKE | |
| SCHEMBL15737255 | 0.78 | IKBKE (0.67) | TBK1IKBKEKITFLT3 | |
| SCHEMBL15736317 | 0.77 | TBK1 (0.61) | TBK1IKBKELSSCSNK2A2CSNK2A1 | |
| SCHEMBL15737873 | 0.75 | TBK1 (0.58) | TBK1IKBKEMEN1KMT2ACSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249114-B2 | Thiazole derivatives | MERCK PATENT GMBH (DE) | 2016-02-02 | — | — | US | disclosed |
| US-20140148457-A1 | Thiazole derivatives | MERCK PATENT GMBH (DE) | 2014-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140148457-A1 | Thiazole derivatives | TBK1, IRAK1, IRF3 | TBK1 1/4885IKBKE 17/4885HRH3 4209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.