Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15536112 | 0.83 | HCRTR1 (0.32) | HCRTR1HCRTR2 | |
| SCHEMBL15749633 | 0.80 | USP2 (0.43) | — | |
| SCHEMBL15740552 | 0.80 | USP2 (0.43) | — | |
| SCHEMBL287972 | 0.71 | — | — | |
| SCHEMBL743510 | 0.70 | — | — | |
| SCHEMBL21724862 | 0.69 | — | — | |
| SCHEMBL21797560 | 0.69 | — | — | |
| SCHEMBL18040915 | 0.69 | — | — | |
| SCHEMBL15543997 | 0.69 | CYP2C19 (0.35) | — | |
| SCHEMBL368420 | 0.67 | VNN1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2922851-A1 | AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS | Genentech, Inc. (US) | 2015-09-30 | — | — | EP | disclosed |
| WO-2014081718-A1 | AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS | GENENTECH, INC. (US) | 2014-05-30 | — | — | WO | disclosed |