Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
| ▸ | GALR2 | O43603 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15740616 | 0.84 | ADRB2 (0.33) | ALDH1A1MEN1KMT2AMAPK1HTT | |
| SCHEMBL15740612 | 0.82 | LATS1 (0.35) | ALDH1A1MEN1KMT2AMAPK1HTT | |
| SCHEMBL30698940 | 0.82 | POLB (0.42) | ALDH1A1MEN1KMT2AMAPK1HTT | |
| SCHEMBL1585679 | 0.82 | POLB (0.42) | ALDH1A1MEN1KMT2AMAPK1HTT | |
| SCHEMBL15740572 | 0.81 | AHR (0.38) | ALDH1A1MEN1KMT2AMAPK1HTT | |
| SCHEMBL28179871 | 0.79 | ALDH1A1 (0.36) | ALDH1A1MEN1KMT2AMAPK1HTT | |
| SCHEMBL15740952 | 0.78 | SMN1; SMN2 (0.34) | ALDH1A1MEN1KMT2AMAPK1HTT | |
| SCHEMBL15749743 | 0.78 | — | — | |
| SCHEMBL5065720 | 0.78 | MAPT (0.45) | ALDH1A1MAPK1HTTLMNAGAA | |
| SCHEMBL15740573 | 0.78 | MAPT (0.46) | ALDH1A1MAPK1HTTCYP1A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014081718-A1 | AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS | GENENTECH, INC. (US) | 2014-05-30 | — | — | WO | disclosed |