Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 8/20 | 0.74 |
| ▸ | THRA | P10827 | 5/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | HRH2 | P25021 | 3/20 | 0.55 |
| ▸ | HRH1 | P35367 | 3/20 | 0.55 |
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.54 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15740778 | 0.94 | THRA (0.69) | THRBTHRAKMT2AHRH2HRH1 | |
| SCHEMBL17107439 | 0.87 | THRB (0.67) | THRBTHRAKMT2AHRH2HRH1 | |
| SCHEMBL17107434 | 0.84 | THRA (0.62) | THRBTHRAHRH2HRH1LTA4H | |
| SCHEMBL15740676 | 0.84 | THRB (0.57) | THRBTHRAHRH2HRH1LTA4H | |
| SCHEMBL7339141 | 0.82 | TSHR (0.76) | THRBTHRAPLA2G4BALDH1A1LMNA | |
| SCHEMBL17107398 | 0.82 | THRA (0.60) | THRBTHRAPLA2G4BALDH1A1LMNA | |
| SCHEMBL15740774 | 0.82 | THRB (0.54) | THRBTHRAHRH2HRH1HRH3 | |
| Hydrochloric Acid SCHEMBL7334829 | 0.81 | TSHR (0.74) | THRBTHRAPLA2G4BALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL6539254 | 0.81 | TSHR (0.74) | THRBTHRAPLA2G4BALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL7330237 | 0.81 | TSHR (0.74) | THRBTHRAPLA2G4BALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925721-A1 | S1P AND/OR ATX MODULATING AGENTS | Biogen MA Inc. (US) | 2015-10-07 | — | — | EP | claimed |
| US-20150274663-A1 | S1P AND/OR ATX MODULATING AGENTS | BIOGEN MA INC. | 2015-10-01 | — | — | US | claimed |
| WO-2014081752-A1 | S1P AND/OR ATX MODULATING AGENTS | BIOGEN IDEC MA INC. (US) | 2014-05-30 | — | — | WO | claimed |
| US-9850206-B2 | S1P and/or ATX modulating agents | BIOGEN MA INC. (US) | 2017-12-26 | — | — | US | disclosed |
| US-9850206-B2 | S1P and/or ATX modulating agents | BIOGEN MA INC. (US) | 2017-12-26 | — | — | US | disclosed |
| EP-2925721-B1 | S1P AND/OR ATX MODULATING AGENTS | BIOGEN MA INC (US) | 2017-06-07 | — | — | EP | disclosed |
| EP-2925721-B1 | S1P AND/OR ATX MODULATING AGENTS | BIOGEN MA INC (US) | 2017-06-07 | — | — | EP | disclosed |
| EP-2925721-A1 | S1P AND/OR ATX MODULATING AGENTS | Biogen MA Inc. (US) | 2015-10-07 | — | — | EP | disclosed |
| US-20150274663-A1 | S1P AND/OR ATX MODULATING AGENTS | BIOGEN MA INC. | 2015-10-01 | — | — | US | disclosed |
| US-20150274663-A1 | S1P AND/OR ATX MODULATING AGENTS | BIOGEN MA INC. | 2015-10-01 | — | — | US | disclosed |
| WO-2014081752-A1 | S1P AND/OR ATX MODULATING AGENTS | BIOGEN IDEC MA INC. (US) | 2014-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274663-A1 | S1P AND/OR ATX MODULATING AGENTS | LPAR3, S1PR3, S1PR1 | THRB 1366/4885THRA 2136/4885KMT2A 3438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.