Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4019697 | 0.79 | SMN1; SMN2 (0.79) | SMN1; SMN2NOTUMALDH1A1MAPTTSHR | |
| SCHEMBL5640305 | 0.77 | SMN1; SMN2 (0.55) | SMN1; SMN2NOTUMALDH1A1MAPTTSHR | |
| SCHEMBL1573664 | 0.75 | ALDH1A1 (0.41) | SMN1; SMN2ALDH1A1MAPTTSHRHTT | |
| SCHEMBL1574211 | 0.74 | NOTUM (0.50) | SMN1; SMN2NOTUMALDH1A1MAPTLMNA | |
| SCHEMBL1574012 | 0.74 | HSP90AA1 (0.44) | SMN1; SMN2NOTUMALDH1A1MAPTMEN1 | |
| SCHEMBL24937726 | 0.72 | SMN1; SMN2 (0.64) | SMN1; SMN2NOTUMALDH1A1MAPTTSHR | |
| SCHEMBL4291340 | 0.71 | SMN1; SMN2 (0.77) | SMN1; SMN2NOTUMALDH1A1MAPTTSHR | |
| SCHEMBL29353444 | 0.71 | SMN1; SMN2 (0.77) | SMN1; SMN2NOTUMALDH1A1MAPTTSHR | |
| SCHEMBL2829456 | 0.71 | SMN1; SMN2 (0.77) | SMN1; SMN2NOTUMALDH1A1MAPTTSHR | |
| SCHEMBL24937798 | 0.70 | NOTUM (0.61) | SMN1; SMN2NOTUMALDH1A1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713779-B1 | INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE-SENSITIVE LIPASES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-04-13 | — | — | EP | disclosed |
| CN-1914180-A | Indazole derivatives as hormone sensitive lipase inhibitors | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-02-14 | — | — | CN | disclosed |