Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2526551 | 0.79 | PARP1 (0.32) | CSNK2A1CSNK2A2PARP1 | |
| SCHEMBL9925954 | 0.76 | PDPK1 (0.34) | PARP1 | |
| SCHEMBL8850 | 0.76 | GDA (0.33) | PARP1 | |
| SCHEMBL16146681 | 0.76 | LMNA (0.33) | PARP1 | |
| SCHEMBL5935894 | 0.76 | CSNK2A1 (0.41) | CSNK2A1CSNK2A2CDK2PARP1 | |
| SCHEMBL135689 | 0.76 | CDK2 (0.52) | CSNK2A1CSNK2A2CDK2PARP1 | |
| SCHEMBL21684954 | 0.76 | CSNK2A1 (0.36) | CSNK2A1CSNK2A2CDK2PARP1 | |
| SCHEMBL5145883 | 0.76 | CSNK2A1 (0.36) | CSNK2A1CSNK2A2CDK2 | |
| SCHEMBL7670280 | 0.73 | PARP1 (0.32) | PARP1 | |
| SCHEMBL20093457 | 0.73 | PARP1 (0.32) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448938-B9 | PYRIMIDINONES AS PI3K INHIBITORS | INCYTE CORP (US) | 2015-06-10 | — | — | EP | disclosed |
| EP-2448938-B1 | PYRIMIDINONES AS PI3K INHIBITORS | INCYTE CORP (US) | 2014-05-28 | — | — | EP | disclosed |