SCHEMBL8850

SCHEMBL8850

Nc1nc(F)nc2[nH]cnc12

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GDA Q9Y2T3 2/20 0.33
PDPK1 O15530 1/20 0.33
AHCY P23526 2/20 0.31
XDH P47989 2/20 0.31
USP2 O75604 1/20 0.31
ALDH1A1 P00352 1/20 0.31
TP53 P04637 1/20 0.31
ADORA3 P0DMS8 1/20 0.31
HPGD P15428 1/20 0.31
PTGS1 P23219 1/20 0.31
MAPK3 P27361 1/20 0.31
HBB P68871 1/20 0.31
PAX8 Q06710 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
PNP P00491 1/20 0.31
LMNA P02545 1/20 0.31
DRD3 P35462 1/20 0.31
PI4KA P42356 1/20 0.31
LRRK2 Q5S007 1/20 0.31
PI4K2B Q8TCG2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11977311 1.00 GDA (0.33) GDAPDPK1AHCYXDHUSP2
SCHEMBL3328520 0.90 MEN1 (0.31) AHCY
Phosphoric Acid SCHEMBL28722665 0.88 ADORA2A (0.32) GDAPARP1
Isoguanine SCHEMBL887740 0.80 PARP1 (0.36) GDAPDPK1XDHUSP2ALDH1A1
2,6-Diaminopurine SCHEMBL24052 0.79 GDA (0.48) GDAPDPK1XDHUSP2ALDH1A1
2,6-Diaminopurine SCHEMBL29444619 0.79 GDA (0.48) GDAPDPK1XDHUSP2ALDH1A1
SCHEMBL2526551 0.79 PARP1 (0.32) PDPK1ALDH1A1TP53HPGDPTGS1
2,6-Diaminopurine SCHEMBL8757968 0.78 GDA (0.47) GDAPDPK1XDHUSP2ALDH1A1
2,6-Diaminopurine SCHEMBL6423146 0.78 GDA (0.47) GDAPDPK1XDHUSP2ALDH1A1
SCHEMBL6545701 0.76 GDA (0.34) GDAPDPK1XDHUSP2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1745 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144879-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS AI-BIOPHARMA (FR) 2026-05-28 US claimed
US-20260146273-A1 METHOD FOR ONE-POT BIOSYNTHESIS OF ARABINONUCLEOSIDE, AND COMPOSITION ASYMCHEM LIFE SCIENCE (TIANJIN) CO., LTD. (CN) 2026-05-28 US claimed
US-12630827-B2 Antisense oligonucleotides targeting SCN2A for the treatment of SCN1A encephalopathies ROGCON, INC. (US) 2026-05-19 US claimed
EP-4606904-A1 METHOD FOR BIOSYNTHESIS OF ARABINONUCLEOSIDE BY ONE-POT METHOD, AND COMPOSITION Asymchem Life Science (Tianjin) Co., Ltd (CN) 2025-08-27 EP claimed
US-12391694-B2 Process for the preparation of 2-fluoroadenine MERCK SHARP & DOHME LLC 2025-08-19 US claimed
US-20250186477-A1 COMPOSITIONS COMPRISING FLUDARABINE PHOSPHATE AND METHODS OF MAKING AND USING SAME TO TREAT CANCER Areva Pharmaceuticals Limited (IE) 2025-06-12 US claimed
US-20250179503-A1 METHODS OF USING OLIGOMERIC COMPOUNDS TO TREAT SCN2A-RELATED DISORDERS PRAXIS PREC MEDICINES INC (US) 2025-06-05 US claimed
EP-4560315-A2 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES F. Hoffmann-La Roche AG (CH) 2025-05-28 EP claimed
US-20250146073-A1 METHODS FOR THE TREATMENT OF SCN2A-RELATED DISORDERS PRAXIS PREC MEDICINES INC (US) 2025-05-08 US claimed
EP-3980554-B1 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES HOFFMANN LA ROCHE (CH) 2025-03-26 EP claimed
EP-0533825-A1 ETHER LIPID-NUCLEOSIDE COVALENT CONJUGATES. UNIV WAKE FOREST (US) 1993-03-31 EP claimed
US-5180824-A 6-AZIDO-2-FLUOROPURINE, USEFUL IN THE SYNTHESIS OF NUCLEOSIDES BERLEX BIOSCIENCES INC. (US) 1993-01-19 US claimed
WO-1992009604-A1 6-AZIDO-2-FLUOROPURINE BERLEX BIOSCIENCES, INC. (US) 1992-06-11 WO claimed
EP-0463999-A1 Improvements in or relating to organic compounds SANDOZ LTD. (CH) 1992-01-02 EP claimed
WO-1991019726-A1 ETHER LIPID-NUCLEOSIDE COVALENT CONJUGATES WAKE FOREST UNIVERSITY (US) 1991-12-26 WO claimed
EP-0456514-A1 2-Fluoroneplanocin A and its production ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1991-11-13 EP claimed
US-4963662-A Fluorinated nucleosides and method for treating retrovirus infections therewith AKADEMIE DER WISSENSCHAFTEN DER DDR (DD) 1990-10-16 US claimed
EP-0254268-B1 FLUORINATED NUCLEOSIDES,THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AGAINST AIDS THE WELLCOME FOUNDATION LIMITED (GB) 1990-09-19 EP claimed
EP-0098122-B1 PROCESSES FOR PRODUCING L-PROLINE BY FERMENTATION KYOWA HAKKO KOGYO CO., LTD. (JP) 1989-05-31 EP claimed
EP-0098122-A2 Processes for producing L-proline by fermentation KYOWA HAKKO KOGYO CO., LTD. (JP) 1984-01-11 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260144879-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS HAVCR2, NR1H4, NR1H3 GDA 4177/4885PDPK1 4288/4885AHCY 3684/4885
US-12630827-B2 Antisense oligonucleotides targeting SCN2A for the treatment of SCN1A encephalopathies SCN1A, SCN2A, SCN1B GDA 629/4885PDPK1 3341/4885AHCY 3140/4885
US-20260146273-A1 METHOD FOR ONE-POT BIOSYNTHESIS OF ARABINONUCLEOSIDE, AND COMPOSITION PNP, UPP1, RNGTT GDA 126/4885PDPK1 713/4885AHCY 487/4885
US-20250179503-A1 METHODS OF USING OLIGOMERIC COMPOUNDS TO TREAT SCN2A-RELATED DISORDERS SCN2A, SCN1A, SCN1B GDA 2010/4885PDPK1 2323/4885AHCY 3502/4885
US-20250186477-A1 COMPOSITIONS COMPRISING FLUDARABINE PHOSPHATE AND METHODS OF MAKING AND USING SAME TO TREAT CANCER BCL9, PAICS, CDA GDA 61/4885PDPK1 482/4885AHCY 292/4885
US-12391694-B2 Process for the preparation of 2-fluoroadenine DCTD, AMPD2, CDA GDA 37/4885PDPK1 2573/4885AHCY 188/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.