Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.50 |
| ▸ | MTOR | P42345 | 15/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.43 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.42 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | NEK2 | P51955 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.42 |
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14240077 | 0.88 | PIK3CA (0.49) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL14239222 | 0.85 | PIK3CA (0.59) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL20430570 | 0.84 | PIK3CA (0.61) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL20430353 | 0.83 | MTOR (0.73) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL15747768 | 0.83 | PIK3CA (0.70) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL31439311 | 0.83 | PIK3CA (0.70) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL15747766 | 0.83 | PIK3CA (0.68) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL31439304 | 0.83 | PIK3CA (0.68) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL14240428 | 0.83 | PIK3CA (0.59) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL14239575 | 0.82 | PIK3CA (0.74) | PIK3CAMTORPIK3CDPIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2719697-B1 | PYRIDONAPHTHYRIDINE PI3K/MTOR DUAL INHIBITORS AND PREPARATION AND USE THEREOF | XUANZHU PHARMA CO LTD (CN) | 2018-08-01 | — | — | EP | disclosed |
| US-9475812-B2 | Pyridonaphthyridine type dual PI3K and mTOR inhibitor and its preparation and use | Xuanzhu Pharma Co., Ltd. (CN) | 2016-10-25 | — | — | US | disclosed |