⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30880446 | 0.83 | MEN1 (0.38) | — | |
| SCHEMBL667646 | 0.83 | — | — | |
| SCHEMBL17006458 | 0.83 | MEN1 (0.38) | — | |
| SCHEMBL758346 | 0.83 | ODC1 (0.41) | — | |
| SCHEMBL5081800 | 0.83 | MEN1 (0.38) | — | |
| SCHEMBL25256307 | 0.83 | MEN1 (0.38) | — | |
| Aminooxyethoxyethoxyethylhydroxylamine SCHEMBL43069 | 0.83 | ODC1 (0.41) | — | |
| SCHEMBL11885390 | 0.83 | ODC1 (0.41) | — | |
| SCHEMBL10076924 | 0.83 | ODC1 (0.41) | — | |
| SCHEMBL9749061 | 0.83 | MEN1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10639381-B2 | Trioxacarcins, trioxacarcin#antibody conjugates, and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2020-05-05 | — | — | US | disclosed |
| EP-2922575-B1 | TRIOXACARCINS, TRIOXACARCIN-ANTIBODY CONJUGATES, AND USES THEREOF | HARVARD COLLEGE (US) | 2019-06-26 | — | — | EP | disclosed |
| US-20180221504-A1 | TRIOXACARCINS, TRIOXACARCIN-ANTIBODY CONJUGATES, AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-08-09 | — | — | US | disclosed |
| US-20180221504-A1 | TRIOXACARCINS, TRIOXACARCIN-ANTIBODY CONJUGATES, AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-08-09 | — | — | US | disclosed |
| US-9775915-B2 | Trioxacarcins, trioxacarcin-antibody conjugates, and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-10-03 | — | — | US | disclosed |
| US-9775915-B2 | Trioxacarcins, trioxacarcin-antibody conjugates, and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-10-03 | — | — | US | disclosed |
| US-20150297747-A1 | TRIOXACARCINS, TRIOXACARCIN-ANTIBODY CONJUGATES, AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-10-22 | — | — | US | disclosed |
| WO-2014082065-A1 | TRIOXACARCINS, TRIOXACARCIN-ANTIBODY CONJUGATES, AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-05-30 | — | — | WO | disclosed |