SCHEMBL758346

SCHEMBL758346

NOCCOCCOCCOCCON

nearest known ligand 0.41

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ODC1 P11926 1/20 0.41
ADRB2 P07550 1/20 0.39
ADRB1 P08588 1/20 0.39
ADRB3 P13945 1/20 0.39
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
TSHR P16473 1/20 0.31
MAPK1 P28482 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL667646 1.00
SCHEMBL11885390 1.00 ODC1 (0.41) ODC1ADRB2ADRB1ADRB3MEN1
Aminooxyethoxyethoxyethylhydroxylamine SCHEMBL43069 1.00 ODC1 (0.41) ODC1ADRB2ADRB1ADRB3MEN1
SCHEMBL10076924 1.00 ODC1 (0.41) ODC1ADRB2ADRB1ADRB3MEN1
Water SCHEMBL20496293 0.96 ODC1 (0.39) ODC1ADRB2ADRB1ADRB3MEN1
SCHEMBL22169531 0.89 ODC1 (0.42) ODC1ADRB2ADRB1ADRB3MEN1
SCHEMBL24500071 0.86 ODC1 (0.47) ODC1ADRB2ADRB1ADRB3MEN1
SCHEMBL16329755 0.86 ODC1 (0.47) ODC1ADRB2ADRB1ADRB3MEN1
SCHEMBL13221671 0.86 ODC1 (0.47) ODC1ADRB2ADRB1ADRB3MEN1
SCHEMBL2127510 0.86

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 133 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160355859-A1 TRANSGLUTAMINASE MEDIATED CONJUGATION OF PEPTIDES NOVO NORDISK A/S (DK) 2016-12-08 US claimed
EP-2033662-B1 Transglutaminase mediated conjugation of peptides NOVO NORDISK HEALTHCARE AG (CH) 2012-10-17 EP claimed
EP-2368579-A1 Transglutaminase mediated conjugation of peptides Novo Nordisk Health Care AG (CH) 2011-09-28 EP claimed
US-20100009917-A1 Modulating Enzymatic Processes by Addition of Diolcontaining Substances NOVO NORDISK HEALTH CARE AG (CH) 2010-01-14 US claimed
US-20090264366-A1 Transglutaminase Mediated Conjugation of Peptides NOVO NORDISK HEALTHCARE AG (CH) 2009-10-22 US claimed
EP-2033662-A1 Transglutaminase mediated conjugation of peptides Novo Nordisk Health Care AG (CH) 2009-03-11 EP claimed
US-20070105770-A1 Transglutaminase mediated conjugation of peptides NOVO NORDISK A/S (DK) 2007-05-10 US claimed
US-12516083-B2 Nucleophilic catalysts for oxime linkage TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2026-01-06 US disclosed
US-20240335549-A1 THERAPEUTIC PROTEINS WITH INCREASED HALF-LIFE AND METHODS OF PREPARING SAME BAXALTA INCORPORATED (US) 2024-10-10 US disclosed
US-11564992-B2 Nucleophilic catalysts for oxime linkage TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2023-01-31 US disclosed
US-11564992-B2 Nucleophilic catalysts for oxime linkage TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2023-01-31 US disclosed
EP-4023247-A1 NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE Takeda Pharmaceutical Company Limited (JP) 2022-07-06 EP disclosed
EP-4019049-A1 METHODS FOR PREPARING THERAPEUTIC PROTEIN-POLYMER CONJUGATES Takeda Pharmaceutical Company Limited (JP) 2022-06-29 EP disclosed
US-7385028-B2 Modified non-natural amino acid polypeptides typically include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group; therapeutic, diagnostic, and other biotechnology uses AMBRX, INC (US) 2008-06-10 US disclosed
US-7332571-B2 Non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, therapeutic, diagnostic, and other biotechnology uses AMBRX, INC. (US) 2008-02-19 US disclosed
US-7332571-B2 Non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, therapeutic, diagnostic, and other biotechnology uses AMBRX, INC. (US) 2008-02-19 US disclosed
US-20070105770-A1 Transglutaminase mediated conjugation of peptides NOVO NORDISK A/S (DK) 2007-05-10 US disclosed
EP-1713508-A2 USE OF AMINO-OXY FUNCTIONAL GROUPS IN THE PREPARATION OF VACCINE CONJUGATES Biosynexus Incorporated (US) 2006-10-25 EP disclosed
WO-2005072778-A2 USE OF AMINO-OXY FUNCTIONAL GROUPS IN THE PREPARATION OF VACCINES CONJUGATES BIOSYNEXUS, INC. (US) 2005-08-11 WO disclosed
US-20050169941-A1 Use of amino-oxy functional groups in the preparation of protein-polysaccharide conjugate vaccines FINA BIOSOLUTIONS, LLC 2005-08-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090264366-A1 Transglutaminase Mediated Conjugation of Peptides TGM2, TGM3, TGM1 ODC1 412/4885ADRB2 4834/4885ADRB1 4813/4885
US-20100009917-A1 Modulating Enzymatic Processes by Addition of Diolcontaining Substances HSD17B14, CES2, PNLIP ODC1 361/4885ADRB2 2061/4885ADRB1 1823/4885
US-11564992-B2 Nucleophilic catalysts for oxime linkage LPO, OGA, DAO ODC1 497/4885ADRB2 4683/4885ADRB1 4649/4885
US-20070105770-A1 Transglutaminase mediated conjugation of peptides TGM2, TGM3, TGM1 ODC1 412/4885ADRB2 4834/4885ADRB1 4813/4885
US-20050169941-A1 Use of amino-oxy functional groups in the preparation of protein-polysaccharide conjugate vaccines OSTC, DAO, OGA ODC1 164/4885ADRB2 4773/4885ADRB1 4754/4885
US-20160355859-A1 TRANSGLUTAMINASE MEDIATED CONJUGATION OF PEPTIDES TGM2, TGM3, TGM1 ODC1 412/4885ADRB2 4834/4885ADRB1 4813/4885
US-20240335549-A1 THERAPEUTIC PROTEINS WITH INCREASED HALF-LIFE AND METHODS OF PREPARING SAME SERPINA6, FCGRT, ALB ODC1 3526/4885ADRB2 4629/4885ADRB1 4708/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.