Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.66 |
| ▸ | USP2 | O75604 | 5/20 | 0.66 |
| ▸ | MEN1 | O00255 | 4/20 | 0.66 |
| ▸ | HTT | P42858 | 4/20 | 0.66 |
| ▸ | TP53 | P04637 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.62 |
| ▸ | GLA | P06280 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22801000 | 0.89 | USP2 (0.65) | POLBALDH1A1KMT2AUSP2MEN1 | |
| SCHEMBL22800996 | 0.82 | HTT (0.67) | POLBALDH1A1KMT2AUSP2MEN1 | |
| SCHEMBL15749613 | 0.80 | ALDH1A1 (0.79) | POLBALDH1A1KMT2AUSP2MEN1 | |
| SCHEMBL22800958 | 0.80 | USP2 (0.57) | POLBALDH1A1KMT2AUSP2MEN1 | |
| SCHEMBL22801006 | 0.80 | USP2 (0.57) | POLBALDH1A1KMT2AUSP2MEN1 | |
| SCHEMBL22828426 | 0.78 | POLB (0.66) | POLBALDH1A1KMT2AUSP2MEN1 | |
| SCHEMBL22800961 | 0.77 | ALDH1A1 (0.66) | POLBALDH1A1KMT2AUSP2MEN1 | |
| SCHEMBL4669803 | 0.77 | TSHR (0.68) | POLBALDH1A1KMT2AUSP2MEN1 | |
| SCHEMBL22800982 | 0.77 | ALDH1A1 (0.64) | POLBALDH1A1KMT2AUSP2MEN1 | |
| SCHEMBL22800978 | 0.77 | USP2 (0.62) | POLBALDH1A1KMT2AUSP2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9546176-B2 | Small molecule bicyclic and tricyclic CFTR correctors | DISCOVERYBIOMED, INC. (US) | 2017-01-17 | — | — | US | disclosed |
| US-9546176-B2 | Small molecule bicyclic and tricyclic CFTR correctors | DISCOVERYBIOMED, INC. (US) | 2017-01-17 | — | — | US | disclosed |
| US-20150307503-A1 | SMALL MOLECULE BICYCLIC AND TRICYCLIC CFTR CORRECTORS | DISCOVERYBIOMED, INC. (US) | 2015-10-29 | — | — | US | disclosed |
| US-20150307503-A1 | SMALL MOLECULE BICYCLIC AND TRICYCLIC CFTR CORRECTORS | DISCOVERYBIOMED, INC. (US) | 2015-10-29 | — | — | US | disclosed |
| WO-2014081821-A2 | Small Molecule Bicyclic and Tricyclic CFTR Correctors | DISCOVERYBIOMED, INC. (US) | 2014-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150307503-A1 | SMALL MOLECULE BICYCLIC AND TRICYCLIC CFTR CORRECTORS | CFTR, CLCN2, CLIC1 | POLB 3476/4885ALDH1A1 3829/4885KMT2A 4504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.