Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | APLNR | P35414 | 1/20 | 0.48 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19427487 | 0.87 | MEN1 (0.62) | KMT2AMEN1TSHRMAPTL3MBTL1 | |
| SCHEMBL15758638 | 0.82 | SMN1; SMN2 (0.66) | KMT2AMEN1MAPTPOLBCYP3A4 | |
| SCHEMBL3707448 | 0.81 | QPCT (0.62) | KMT2AMEN1MAPTALDH1A1HTR2A | |
| SCHEMBL19427445 | 0.79 | ALDH1A1 (0.75) | KMT2AMEN1MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL19427481 | 0.78 | KMT2A (0.68) | KMT2AMEN1TSHRMAPTPOLB | |
| SCHEMBL15758031 | 0.77 | EPHX2 (0.70) | KMT2AMEN1MAPTALDH1A1TP53 | |
| SCHEMBL4362583 | 0.77 | MEN1 (0.64) | KMT2AMEN1TSHRPOLBALDH1A1 | |
| SCHEMBL19427517 | 0.76 | HSD17B10 (0.60) | KMT2AMEN1TSHRPOLBALDH1A1 | |
| SCHEMBL26090723 | 0.76 | MEN1 (0.50) | KMT2AMEN1TSHRMAPTALDH1A1 | |
| SCHEMBL26090714 | 0.76 | MEN1 (0.50) | KMT2AMEN1TSHRMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10912761-B2 | Methods and compositions involving RAD51 inhibitors | THE UNIVERSITY OF CHICAGO (US) | 2021-02-09 | — | — | US | disclosed |
| US-20150306069-A1 | METHODS AND COMPOSITIONS INVOLVING RAD51 INHIBITORS | THE UNIVERSITY OF CHICAGO (US) | 2015-10-29 | — | — | US | disclosed |
| WO-2014085545-A1 | METHODS AND COMPOSITIONS INVOLVING RAD51 INHIBITORS | THE UNIVERSITY OF CHICAGO (US) | 2014-06-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10912761-B2 | Methods and compositions involving RAD51 inhibitors | RAD51, MRE11, RAD50 | KMT2A 1387/4885MEN1 2019/4885TSHR 4391/4885 |
| US-20150306069-A1 | METHODS AND COMPOSITIONS INVOLVING RAD51 INHIBITORS | RAD51, MRE11, RAD50 | KMT2A 1387/4885MEN1 2019/4885TSHR 4391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.