SCHEMBL15764151

SCHEMBL15764151

Nc1ccc2c(NCl)c3ccccc3nc2c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 5/20 0.54
HTR3A P46098 1/20 0.47
KDM4E B2RXH2 3/20 0.46
ALDH1A1 P00352 3/20 0.46
GLA P06280 3/20 0.46
ACHE P22303 3/20 0.46
MAOA P21397 3/20 0.46
HPGD P15428 2/20 0.46
CASP1 P29466 2/20 0.46
CASP7 P55210 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
HSD17B10 Q99714 2/20 0.46
TDP1 Q9NUW8 2/20 0.46
CHRM2 P08172 2/20 0.46
ADRA2A P08913 2/20 0.46
ADORA3 P0DMS8 2/20 0.46
DRD1 P21728 2/20 0.46
SLC6A2 P23975 2/20 0.46
OPRM1 P35372 2/20 0.46
KCNH2 Q12809 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13912471 0.84 KDM1A (0.59) KDM1AKDM4EALDH1A1GLAACHE
SCHEMBL17154394 0.81 KDM1A (0.84) KDM1AKDM4EGLAACHESMN1; SMN2
SCHEMBL4163642 0.80 KDM4E (0.72) KDM1AHTR3AKDM4EALDH1A1GLA
SCHEMBL11703495 0.77 HTR3A (0.52) KDM1AHTR3AKDM4EALDH1A1GLA
SCHEMBL11704426 0.76 ESR1 (0.64) KDM1AHTR3AKDM4EALDH1A1GLA
SCHEMBL7869229 0.75 KDM1A (0.53) KDM1AHTR3AKDM4EALDH1A1GLA
SCHEMBL11454787 0.75 ESR1 (0.57) KDM1AHTR3AKDM4EALDH1A1GLA
SCHEMBL17742244 0.73 HTR3A (0.47) KDM1AHTR3AKDM4EALDH1A1GLA
SCHEMBL11703072 0.73 KDM4E (0.51) KDM1AHTR3AKDM4EALDH1A1GLA
SCHEMBL7875795 0.73 KDM1A (0.50) KDM1AHTR3AKDM4EALDH1A1GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140151548-A1 MATRIX FOR MALDI MASS SPECTROMETRY AND MALDIMASS SPECTROMETRY METHOD KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION (JP) 2014-06-05 US disclosed