Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 13/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | RAD52 | P43351 | 3/20 | 0.55 |
| ▸ | GFER | P55789 | 2/20 | 0.55 |
| ▸ | TOP2A | P11388 | 1/20 | 0.55 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17154453 | 0.92 | KDM1A (0.69) | KDM1AKMT2APOLBRAD52GFER | |
| SCHEMBL17154450 | 0.92 | KDM1A (1.00) | KDM1AKMT2APOLBRAD52GFER | |
| SCHEMBL31237457 | 0.86 | KDM1A (0.78) | KDM1AKMT2ARAD52GFERTOP2A | |
| SCHEMBL17154399 | 0.86 | KDM1A (0.62) | KDM1AKMT2APOLBRAD52TOP2A | |
| SCHEMBL17154363 | 0.83 | KDM1A (0.58) | KDM1AKMT2APOLBRAD52GFER | |
| SCHEMBL17154392 | 0.83 | KMT2A (0.74) | KDM1AKMT2APOLBKDM4EMAPT | |
| SCHEMBL17154362 | 0.83 | KDM1A (0.74) | KDM1AKMT2APOLBRAD52ATM | |
| SCHEMBL17154397 | 0.81 | KDM1A (0.68) | KDM1AKMT2APOLBRAD52GFER | |
| SCHEMBL15764151 | 0.81 | KDM1A (0.54) | KDM1AKMT2APOLBRAD52TOP2A | |
| SCHEMBL18407164 | 0.80 | TOP2A (0.73) | KDM1AKMT2APOLBRAD52GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10183912-B2 | HDMX inhibitors and their use for cancer treatment | MiRx Pharmaceuticals, LLC (US) | 2019-01-22 | — | — | US | disclosed |
| US-20170022166-A1 | NOVEL HDMX INHIBITORS AND THEIR USE FOR CANCER TREATMENT | MIRX PHARMACEUTICALS LLC (US) | 2017-01-26 | — | — | US | disclosed |
| US-20170022166-A1 | NOVEL HDMX INHIBITORS AND THEIR USE FOR CANCER TREATMENT | MIRX PHARMACEUTICALS LLC (US) | 2017-01-26 | — | — | US | disclosed |
| WO-2015153535-A1 | NOVEL HDMX INHIBITORS AND THEIR USE FOR CANCER TREATMENT | MiRx Pharmaceuticals, LLC (US) | 2015-10-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170022166-A1 | NOVEL HDMX INHIBITORS AND THEIR USE FOR CANCER TREATMENT | TP53, DDX3X, API5 | KDM1A 702/4885KMT2A 1544/4885POLB 3707/4885 |
| US-10183912-B2 | HDMX inhibitors and their use for cancer treatment | TP53, MDM4, MDM2 | KDM1A 650/4885KMT2A 1514/4885POLB 3690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.