Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | STAT6 | P42226 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12748249 | 0.89 | TSPO (0.43) | TSPOALDH1A1MAPTTAS1R3TAS1R1 | |
| SCHEMBL12748246 | 0.89 | TSPO (0.43) | TSPOALDH1A1MAPTTAS1R3TAS1R1 | |
| SCHEMBL12748227 | 0.89 | TSPO (0.43) | TSPOALDH1A1MAPTTAS1R3TAS1R1 | |
| SCHEMBL420135 | 0.89 | TSPO (0.41) | TSPOALDH1A1MAPTKMT2APKM | |
| SCHEMBL6688729 | 0.86 | TSPO (0.43) | TSPOALDH1A1KMT2A | |
| SCHEMBL416930 | 0.85 | TSPO (0.54) | TSPO | |
| SCHEMBL12748229 | 0.80 | TSPO (0.44) | TSPOALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL12748236 | 0.80 | TSPO (0.44) | TSPOALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL12748241 | 0.80 | TSPO (0.44) | TSPOALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL416598 | 0.79 | TSPO (0.42) | TSPOKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10709798-B2 | Crystallization process of tricyclic indole derivatives | GE HEALTHCARE LIMITED (GB) | 2020-07-14 | — | — | US | disclosed |
| US-20150335766-A1 | CRYSTALLIZATION PROCESS OF TRICYCLIC INDOLE DERIVATIVES | GE HEALTHCARE LIMITED (GB) | 2015-11-26 | — | — | US | disclosed |
| US-20150335766-A1 | CRYSTALLIZATION PROCESS OF TRICYCLIC INDOLE DERIVATIVES | GE HEALTHCARE LIMITED (GB) | 2015-11-26 | — | — | US | disclosed |
| WO-2014083113-A1 | CRYSTALLIZATION PROCESS OF TRICYCLIC INDOLE DERIVATIVES | GE HEALTHCARE LIMITED (GB) | 2014-06-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150335766-A1 | CRYSTALLIZATION PROCESS OF TRICYCLIC INDOLE DERIVATIVES | IDO1, IDO2, TPH1 | TSPO 3643/4885ALDH1A1 3828/4885MAPT 31/4885 |
| US-10709798-B2 | Crystallization process of tricyclic indole derivatives | IDO1, IDO2, TPH1 | TSPO 3643/4885ALDH1A1 3828/4885MAPT 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.