Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.70 |
| ▸ | RAB9A | P51151 | 5/20 | 0.70 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.69 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.69 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.69 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.69 |
| ▸ | CLK2 | P49760 | 2/20 | 0.69 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.69 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.69 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.69 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.69 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.69 |
| ▸ | MAOB | P27338 | 4/20 | 0.68 |
| ▸ | JAK2 | O60674 | 2/20 | 0.65 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.62 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.62 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.62 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.62 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.62 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16888856 | 0.84 | NPC1 (0.64) | NPC1RAB9AROCK2ROCK1MAP4K4 | |
| SCHEMBL5415117 | 0.84 | MAOB (0.80) | NPC1RAB9AROCK2ROCK1MAP4K4 | |
| SCHEMBL7261149 | 0.82 | NPC1 (0.68) | NPC1RAB9AROCK2ROCK1MAP4K4 | |
| SCHEMBL1664461 | 0.82 | NPC1 (1.00) | NPC1RAB9AROCK2ROCK1MAP4K4 | |
| SCHEMBL15764676 | 0.82 | NPC1 (1.00) | NPC1RAB9AROCK2ROCK1MAP4K4 | |
| SCHEMBL18668994 | 0.81 | MAOB (0.84) | NPC1RAB9AROCK2ROCK1MAP4K4 | |
| SCHEMBL15887002 | 0.80 | MAOB (0.81) | NPC1RAB9AROCK2ROCK1MAP4K4 | |
| SCHEMBL15764656 | 0.80 | NPC1 (0.81) | NPC1RAB9AROCK2ROCK1MAP4K4 | |
| SCHEMBL5707229 | 0.80 | NPC1 (0.72) | NPC1RAB9AROCK2ROCK1MAP4K4 | |
| SCHEMBL5414918 | 0.80 | NPC1 (0.85) | NPC1RAB9AROCK2ROCK1MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951316-B2 | Enhancers of induced pluripotent stem cell reprogramming | CITY OF HOPE (US) | 2018-04-24 | — | — | US | disclosed |
| US-20150191701-A1 | ENHANCERS OF INDUCED PLURIPOTENT STEM CELL REPROGRAMMING | CITY OF HOPE | 2015-07-09 | — | — | US | disclosed |
| US-8962322-B2 | Enhancers of induced pluripotent stem cell reprogramming | CITY OF HOPE | 2015-02-24 | — | — | US | disclosed |
| US-20140154805-A1 | ENHANCERS OF INDUCED PLURIPOTENT STEM CELL REPROGRAMMING | CITY OF HOPE (US) | 2014-06-05 | — | — | US | disclosed |