SCHEMBL1576775

SCHEMBL1576775

COc1ccc(Cn2nc(NC(=O)NCCCl)cc2C(=O)O)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FPR2 P25090 4/20 0.44
MAPT P10636 2/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
CNR1 P21554 1/20 0.42
PTGER4 P35408 2/20 0.42
PIM1 P11309 1/20 0.41
ALDH1A1 P00352 2/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2C19 P33261 1/20 0.41
CACNA1G O43497 1/20 0.41
CACNA1H O95180 1/20 0.41
CACNA1I Q9P0X4 1/20 0.41
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
CCR2 P41597 1/20 0.40
ROCK2 O75116 1/20 0.40
ROCK1 Q13464 1/20 0.40
GRN P28799 1/20 0.40
SORT1 Q99523 1/20 0.40
KCNJ6 P48051 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1576694 0.92 MAPT (0.44) FPR2MAPTSMN1; SMN2CNR1ALDH1A1
SCHEMBL14397153 0.79 MAPT (0.44) MAPTSMN1; SMN2PTGER4ALDH1A1CACNA1G
SCHEMBL1577065 0.77 MAPT (0.46) MAPTSMN1; SMN2ALDH1A1CYP1A2CYP2C19
SCHEMBL13387618 0.76 MAPT (0.47) MAPTSMN1; SMN2PTGER4ALDH1A1CYP1A2
SCHEMBL22489117 0.76 NPC1 (0.50) MAPTSMN1; SMN2PTGER4ALDH1A1CYP1A2
SCHEMBL14119926 0.75 MAPT (0.50) MAPTSMN1; SMN2PTGER4ALDH1A1NPC1
SCHEMBL10150650 0.75 MAPT (0.53) MAPTSMN1; SMN2ALDH1A1NPC1RAB9A
SCHEMBL1883988 0.75 ALDH1A1 (0.53) MAPTSMN1; SMN2PTGER4ALDH1A1CYP1A2
SCHEMBL6340205 0.74 BRD4 (0.44) PTGER4ALDH1A1GRNSORT1LMNA
SCHEMBL25314890 0.72 ALDH1A1 (0.45) MAPTSMN1; SMN2PTGER4ALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2483264-A1 PYRAZOLE DERIVATIVES WHICH MODULATE STEAROYL-COA DESATURASE Novartis AG (CH) 2012-08-08 EP disclosed
WO-2011039358-A1 PYRAZOLE DERIVATIVES WHICH MODULATE STEAROYL-COA DESATURASE NOVARTIS AG (CH) 2011-04-07 WO disclosed