Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.42 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.38 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 6/20 | 0.37 |
| ▸ | MAOA | P21397 | 6/20 | 0.37 |
| ▸ | MAOB | P27338 | 6/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12498386 | 1.00 | SLC6A4 (0.42) | SLC6A4SLC9A1SLC10A2KDM1AMAOA | |
| SCHEMBL15768762 | 0.83 | SLC6A4 (0.36) | SLC6A4SLC9A1SLC10A2KDM1AMAOA | |
| SCHEMBL12498953 | 0.83 | SLC6A4 (0.36) | SLC6A4SLC9A1SLC10A2KDM1AMAOA | |
| SCHEMBL15768959 | 0.83 | SLC9A1 (0.38) | SLC6A4SLC9A1KDM1AMAOAMAOB | |
| SCHEMBL12499506 | 0.83 | SLC9A1 (0.38) | SLC6A4SLC9A1KDM1AMAOAMAOB | |
| SCHEMBL12498987 | 0.79 | LMNA (0.49) | ADORA3SMN1; SMN2 | |
| SCHEMBL12498121 | 0.78 | MEN1 (0.48) | MAOAMAOBHDAC4HTTGAA | |
| SCHEMBL12498918 | 0.78 | HDAC4 (0.42) | SLC6A4SLC9A1KDM1AHDAC4CYP2D6 | |
| SCHEMBL15768564 | 0.78 | MEN1 (0.48) | MAOAMAOBHDAC4HTTGAA | |
| SCHEMBL15768826 | 0.78 | HDAC4 (0.44) | SLC6A4SLC9A1HDAC4CYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765054-B2 | Histone deacetylase inhibitors and compositions and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-20140163009-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI Foundation (US) | 2014-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140163009-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | HDAC1, HDAC7, HDAC5 | SLC6A4 4626/4885SLC9A1 2641/4885SLC10A2 1772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.