Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA4 | P22748 | 2/20 | 0.50 |
| ▸ | CA6 | P23280 | 2/20 | 0.50 |
| ▸ | CA7 | P43166 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.50 |
| ▸ | CA3 | P07451 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.50 |
| ▸ | TPMT | P51580 | 2/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27619794 | 0.88 | CA12 (0.50) | CA12CA1CA2CA4CA6 | |
| SCHEMBL15774869 | 0.86 | TSHR (0.53) | POLBHTTRXFP1TUBB4ATUBB | |
| SCHEMBL14217542 | 0.85 | KDM4E (0.51) | CA12CA1CA2CA4CA6 | |
| SCHEMBL15774677 | 0.81 | HSD17B2 (0.52) | CA12CA1CA2CA7CA9 | |
| SCHEMBL15775076 | 0.80 | POLB (0.42) | POLBRXFP1LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL18288064 | 0.79 | ALOX15 (0.55) | CA12CA1CA2CA4CA6 | |
| SCHEMBL10702559 | 0.76 | HTT (0.56) | CA12CA1CA2CA4CA6 | |
| SCHEMBL8960918 | 0.76 | CA12 (0.62) | CA12CA1CA2CA4CA6 | |
| SCHEMBL28857298 | 0.75 | CA1 (0.69) | CA12CA1CA2CA4CA6 | |
| SCHEMBL11507377 | 0.75 | POLB (0.56) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014086697-A1 | SUBSTITUTED THIAZOLE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-06-12 | — | — | WO | disclosed |