Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 12/20 | 0.68 |
| ▸ | TNKS2 | Q9H2K2 | 12/20 | 0.68 |
| ▸ | PARP2 | Q9UGN5 | 7/20 | 0.68 |
| ▸ | PARP1 | P09874 | 5/20 | 0.53 |
| ▸ | GUSB | P08236 | 1/20 | 0.51 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | STAT1 | P42224 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775528 | 0.84 | TNKS (0.66) | TNKSTNKS2PARP2PARP1GUSB | |
| SCHEMBL15775404 | 0.84 | TNKS (0.64) | TNKSTNKS2PARP2PARP1GUSB | |
| SCHEMBL15775468 | 0.84 | TNKS (0.64) | TNKSTNKS2PARP2PARP1MAPT | |
| SCHEMBL15775359 | 0.84 | TNKS (0.64) | TNKSTNKS2PARP2PARP1MAPT | |
| SCHEMBL15775406 | 0.83 | TNKS (0.63) | TNKSTNKS2PARP2PARP1GUSB | |
| SCHEMBL15775172 | 0.83 | TNKS (0.65) | TNKSTNKS2PARP2PARP1GUSB | |
| SCHEMBL15775271 | 0.83 | TNKS (0.65) | TNKSTNKS2PARP2PARP1MAPT | |
| SCHEMBL15775408 | 0.83 | TNKS (0.65) | TNKSTNKS2PARP2PARP1MAPT | |
| SCHEMBL15775574 | 0.82 | TNKS (0.54) | TNKSTNKS2PARP2PARP1GUSB | |
| SCHEMBL1387250 | 0.81 | TNKS (0.66) | TNKSTNKS2PARP2PARP1GUSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |