Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 4/20 | 0.54 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.54 |
| ▸ | PARP1 | P09874 | 3/20 | 0.54 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.52 |
| ▸ | GUSB | P08236 | 2/20 | 0.52 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.52 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.48 |
| ▸ | MMP2 | P08253 | 3/20 | 0.46 |
| ▸ | MMP9 | P14780 | 3/20 | 0.46 |
| ▸ | MMP8 | P22894 | 3/20 | 0.46 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MMP13 | P45452 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775528 | 0.85 | TNKS (0.66) | TNKSTNKS2PARP1PARP2GUSB | |
| SCHEMBL1387250 | 0.82 | TNKS (0.66) | TNKSTNKS2PARP1PARP2GUSB | |
| SCHEMBL15775263 | 0.82 | TNKS (0.68) | TNKSTNKS2PARP1PARP2GUSB | |
| SCHEMBL15775576 | 0.81 | TNKS (0.74) | TNKSTNKS2PARP1PARP2GUSB | |
| SCHEMBL15775355 | 0.77 | MMP2 (0.68) | TNKSTNKS2PARP1PARP2GUSB | |
| SCHEMBL2126968 | 0.71 | TNKS (0.59) | TNKSTNKS2PARP1PARP2GUSB | |
| SCHEMBL6330688 | 0.70 | MMP2 (0.62) | TNKSTNKS2PARP1PARP2GUSB | |
| SCHEMBL15775530 | 0.70 | TNKS (1.00) | TNKSTNKS2PARP1PARP2GUSB | |
| SCHEMBL15775356 | 0.69 | TNKS (1.00) | TNKSTNKS2PARP1PARP2GUSB | |
| SCHEMBL10871321 | 0.68 | ADORA2B (0.54) | TNKSTNKS2PARP1PARP2GUSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |