Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 13/20 | 0.65 |
| ▸ | TNKS2 | Q9H2K2 | 13/20 | 0.65 |
| ▸ | PARP1 | P09874 | 7/20 | 0.65 |
| ▸ | PARP2 | Q9UGN5 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | NQO2 | P16083 | 1/20 | 0.45 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775468 | 0.88 | TNKS (0.64) | TNKSTNKS2PARP1PARP2KDM4E | |
| SCHEMBL15775359 | 0.88 | TNKS (0.64) | TNKSTNKS2PARP1PARP2KDM4E | |
| SCHEMBL15775404 | 0.88 | TNKS (0.64) | TNKSTNKS2PARP1PARP2KDM4E | |
| SCHEMBL15775406 | 0.88 | TNKS (0.63) | TNKSTNKS2PARP1PARP2KDM4E | |
| SCHEMBL15775408 | 0.87 | TNKS (0.65) | TNKSTNKS2PARP1PARP2KDM4E | |
| SCHEMBL15775172 | 0.87 | TNKS (0.65) | TNKSTNKS2PARP1PARP2KDM4E | |
| SCHEMBL15775334 | 0.84 | TNKS (0.67) | TNKSTNKS2PARP1PARP2KDM4E | |
| SCHEMBL15775263 | 0.83 | TNKS (0.68) | TNKSTNKS2PARP1PARP2MEN1 | |
| SCHEMBL15775690 | 0.82 | TNKS (0.63) | TNKSTNKS2PARP1PARP2KDM4E | |
| SCHEMBL15775482 | 0.80 | PARP1 (0.63) | TNKSTNKS2PARP1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |