Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 15/20 | 0.63 |
| ▸ | TNKS | O95271 | 14/20 | 0.63 |
| ▸ | TNKS2 | Q9H2K2 | 14/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GUSB | P08236 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775567 | 0.88 | PARP1 (0.61) | PARP1TNKSTNKS2KDM4EGUSB | |
| SCHEMBL15775644 | 0.87 | TNKS (0.60) | PARP1TNKSTNKS2KDM4EGUSB | |
| SCHEMBL15775241 | 0.86 | TNKS (0.63) | PARP1TNKSTNKS2TP53MAPT | |
| SCHEMBL15775381 | 0.86 | TNKS (0.63) | PARP1TNKSTNKS2NPC1RAB9A | |
| SCHEMBL15775691 | 0.86 | TNKS (0.63) | PARP1TNKSTNKS2KDM4E | |
| SCHEMBL15775320 | 0.86 | TNKS (0.63) | PARP1TNKSTNKS2GUSBEGFR | |
| SCHEMBL15775690 | 0.83 | TNKS (0.63) | PARP1TNKSTNKS2NPC1POLB | |
| SCHEMBL15775430 | 0.82 | TNKS (0.65) | PARP1TNKSTNKS2RAB9A | |
| SCHEMBL1387250 | 0.81 | TNKS (0.66) | PARP1TNKSTNKS2NPC1RAB9A | |
| SCHEMBL15775271 | 0.80 | TNKS (0.65) | PARP1TNKSTNKS2POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |