Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 13/20 | 0.68 |
| ▸ | PARP1 | P09874 | 7/20 | 0.68 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | WNT3A | P56704 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775783 | 0.84 | TNKS (0.71) | TNKSPARP1TNKS2PARP2 | |
| SCHEMBL15775466 | 0.83 | PARP1 (0.63) | TNKSPARP1TNKS2 | |
| SCHEMBL15775421 | 0.82 | TNKS (0.73) | TNKSPARP1TNKS2PARP2HDAC11 | |
| SCHEMBL15775959 | 0.81 | TNKS (0.76) | TNKSPARP1TNKS2PARP2HDAC11 | |
| SCHEMBL15775897 | 0.77 | PARP1 (0.65) | TNKSPARP1TNKS2PARP2HDAC11 | |
| SCHEMBL4763725 | 0.76 | TNKS (0.64) | TNKSPARP1TNKS2PARP2HDAC11 | |
| SCHEMBL15569103 | 0.74 | TNKS (0.60) | TNKSPARP1TNKS2PARP2 | |
| SCHEMBL15775399 | 0.73 | TNKS (0.63) | TNKSPARP1 | |
| SCHEMBL15568122 | 0.73 | PARP1 (0.64) | TNKSPARP1TNKS2 | |
| SCHEMBL15693152 | 0.73 | TNKS (0.50) | TNKSPARP1TNKS2PARP2HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |