Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.65 |
| ▸ | TNKS | O95271 | 8/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15776207 | 0.86 | TNKS (0.60) | PARP1TNKSALDH1A1TNKS2TDP1 | |
| SCHEMBL15775582 | 0.84 | PARP1 (0.60) | PARP1TNKSALDH1A1TNKS2TDP1 | |
| SCHEMBL15775461 | 0.83 | PARP1 (0.63) | PARP1TNKSALDH1A1TNKS2TDP1 | |
| SCHEMBL15775766 | 0.83 | PARP1 (0.63) | PARP1TNKSALDH1A1TNKS2TDP1 | |
| SCHEMBL15775421 | 0.80 | TNKS (0.73) | PARP1TNKSHDAC11TNKS2WNT3A | |
| SCHEMBL15775317 | 0.80 | PARP1 (0.65) | PARP1TNKSALDH1A1TNKS2 | |
| SCHEMBL15775783 | 0.79 | TNKS (0.71) | PARP1TNKSTNKS2PARP2 | |
| SCHEMBL15775348 | 0.77 | TNKS (0.68) | PARP1TNKSHDAC11TNKS2WNT3A | |
| SCHEMBL15775959 | 0.76 | TNKS (0.76) | PARP1TNKSHDAC11TNKS2WNT3A | |
| SCHEMBL4763725 | 0.74 | TNKS (0.64) | PARP1TNKSALDH1A1HDAC11TNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |