Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.63 |
| ▸ | TNKS | O95271 | 10/20 | 0.49 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CTSV | O60911 | 2/20 | 0.45 |
| ▸ | CTSL | P07711 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TUBB | P07437 | 1/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.45 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.45 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.45 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.45 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.45 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.45 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.45 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775348 | 0.83 | TNKS (0.68) | PARP1TNKSTNKS2 | |
| SCHEMBL31014299 | 0.81 | PARP1 (0.67) | PARP1TNKSTNKS2KDM4EHPGD | |
| SCHEMBL15775395 | 0.81 | PARP1 (0.67) | PARP1TNKSTNKS2KDM4EHPGD | |
| SCHEMBL15775297 | 0.78 | PARP1 (0.67) | PARP1TNKSTNKS2KDM4ECTSV | |
| SCHEMBL15775666 | 0.78 | PARP1 (1.00) | PARP1TNKSTNKS2KDM4ECTSV | |
| SCHEMBL15775399 | 0.77 | TNKS (0.63) | PARP1TNKS | |
| SCHEMBL9447439 | 0.77 | TNKS (0.79) | PARP1TNKSTNKS2HPGDALDH1A1 | |
| SCHEMBL16625151 | 0.76 | TNKS (0.78) | PARP1TNKS | |
| SCHEMBL17859651 | 0.73 | KDM4E (0.53) | PARP1TNKS2KDM4EHPGDTP53 | |
| SCHEMBL29639160 | 0.73 | TNKS (0.63) | PARP1TNKSTNKS2KDM4ECTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |