Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 13/20 | 0.68 |
| ▸ | TNKS2 | Q9H2K2 | 12/20 | 0.68 |
| ▸ | PARP1 | P09874 | 6/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.60 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.57 |
| ▸ | GUSB | P08236 | 5/20 | 0.55 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.55 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.55 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | WNT3A | P56704 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30440950 | 0.87 | HPGD (0.65) | TNKSTNKS2PARP1ALDH1A1HPGD | |
| SCHEMBL258433 | 0.81 | TNKS (1.00) | TNKSTNKS2PARP1ALDH1A1HPGD | |
| SCHEMBL29592833 | 0.81 | TNKS (1.00) | TNKSTNKS2PARP1ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL31529601 | 0.80 | TNKS (0.96) | TNKSTNKS2PARP1ALDH1A1HPGD | |
| SCHEMBL2617083 | 0.80 | TNKS (0.77) | TNKSTNKS2PARP1ALDH1A1HPGD | |
| SCHEMBL6124189 | 0.78 | TNKS (0.93) | TNKSTNKS2PARP1ALDH1A1HPGD | |
| SCHEMBL6885282 | 0.78 | TNKS (0.93) | TNKSTNKS2PARP1ALDH1A1HPGD | |
| SCHEMBL14259681 | 0.76 | TNKS (0.66) | TNKSTNKS2PARP1ALDH1A1HPGD | |
| SCHEMBL2744822 | 0.76 | NPC1 (0.61) | TNKSTNKS2PARP1ALDH1A1HPGD | |
| SCHEMBL3460177 | 0.75 | HPGD (1.00) | TNKSTNKS2PARP1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |