Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 1.00 |
| ▸ | TNKS | O95271 | 13/20 | 0.81 |
| ▸ | TNKS2 | Q9H2K2 | 12/20 | 0.81 |
| ▸ | PARP1 | P09874 | 6/20 | 0.81 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.72 |
| ▸ | GUSB | P08236 | 6/20 | 0.69 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.69 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.69 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.69 |
| ▸ | WNT3A | P56704 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | CASP3 | P42574 | 1/20 | 0.64 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.64 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29831923 | 1.00 | HPGD (1.00) | HPGDMAPTALDH1A1ALOX15HSD17B10 | |
| SCHEMBL258433 | 0.90 | TNKS (1.00) | HPGDMAPTALDH1A1ALOX15HSD17B10 | |
| SCHEMBL6885282 | 0.90 | TNKS (0.93) | HPGDMAPTALDH1A1ALOX15HSD17B10 | |
| SCHEMBL29592833 | 0.90 | TNKS (1.00) | HPGDMAPTALDH1A1ALOX15HSD17B10 | |
| Hydrochloric Acid SCHEMBL31529601 | 0.88 | TNKS (0.96) | HPGDMAPTALDH1A1ALOX15HSD17B10 | |
| SCHEMBL6124189 | 0.86 | TNKS (0.93) | HPGDMAPTALDH1A1ALOX15HSD17B10 | |
| SCHEMBL14344501 | 0.84 | KDM4C (1.00) | HPGDMAPTALDH1A1ALOX15HSD17B10 | |
| SCHEMBL6695759 | 0.84 | TNKS2 (0.81) | HPGDMAPTALDH1A1ALOX15HSD17B10 | |
| SCHEMBL15645718 | 0.83 | KDM4C (0.82) | HPGDMAPTALDH1A1ALOX15HSD17B10 | |
| SCHEMBL20299026 | 0.83 | HPGD (0.71) | HPGDMAPTALDH1A1ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11407719-B2 | Anti-inflammatory agents | RESVERLOGIX CORP. (CA) | 2022-08-09 | — | — | US | disclosed |
| US-20210070716-A1 | ANTI-INFLAMMATORY AGENTS | HEPALINK (HONG KONG) LIMITED (HK) | 2021-03-11 | — | — | US | disclosed |
| CN-104557738-A | Green synthesis method of 4(3H)-quinazolinone | UNIV HUNAN | 2015-04-29 | — | — | CN | disclosed |
| US-7763627-B2 | Tie-2 modulators and methods of use | EXELIXIS, INC. (US) | 2010-07-27 | — | — | US | disclosed |
| EP-1610774-A4 | TIE-2 MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2008-07-16 | — | — | EP | disclosed |
| US-20070161651-A1 | Tie-2 modulators and methods of use | EXELIXIS, INC. (US) | 2007-07-12 | — | — | US | disclosed |
| US-20060128702-A1 | Heterocyclic and bicyclic compounds, compositions and methods | REDDY US THERAPEUTICS, INC. | 2006-06-15 | — | — | US | disclosed |
| EP-1610774-A2 | TIE-2 MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004092196-A2 | TIE-2 MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2004-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161651-A1 | Tie-2 modulators and methods of use | TIE1, TEK, KDR | HPGD 1856/4885MAPT 2716/4885ALDH1A1 3053/4885 |
| US-11407719-B2 | Anti-inflammatory agents | VCAM1, ICAM1, IL6 | HPGD 1083/4885MAPT 2112/4885ALDH1A1 587/4885 |
| US-20060128702-A1 | Heterocyclic and bicyclic compounds, compositions and methods | HPSE, ENGASE, UGCG | HPGD 189/4885MAPT 4070/4885ALDH1A1 2033/4885 |
| US-20210070716-A1 | ANTI-INFLAMMATORY AGENTS | VCAM1, ICAM1, IL6 | HPGD 1083/4885MAPT 2112/4885ALDH1A1 587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.