Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | CCR1 | P32246 | 2/20 | 0.38 |
| ▸ | CCR8 | P51685 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | CDC7 | O00311 | 3/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.34 |
| ▸ | PIM1 | P11309 | 3/20 | 0.34 |
| ▸ | PRKACA | P17612 | 3/20 | 0.34 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20009341 | 0.81 | PIP4K2C (0.40) | LMNAPIP4K2CL3MBTL1CCR1CCR8 | |
| SCHEMBL19249763 | 0.81 | PIP4K2C (0.40) | LMNAPIP4K2CL3MBTL1CCR1CCR8 | |
| SCHEMBL21856545 | 0.80 | GRM5 (0.41) | LMNAL3MBTL1CCR1CCR8ALDH1A1 | |
| SCHEMBL19250465 | 0.78 | PIP4K2C (0.38) | LMNAPIP4K2CL3MBTL1CCR1CCR8 | |
| SCHEMBL1577423 | 0.77 | CCR1 (0.49) | LMNAL3MBTL1CCR1CCR8ALDH1A1 | |
| SCHEMBL247512 | 0.77 | L3MBTL1 (0.52) | LMNAL3MBTL1CCR1CCR8ALDH1A1 | |
| SCHEMBL8212392 | 0.77 | G6PD (0.48) | LMNAL3MBTL1CCR1CCR8ALDH1A1 | |
| SCHEMBL1577375 | 0.76 | PIP4K2C (0.39) | LMNAPIP4K2CL3MBTL1CCR1CCR8 | |
| SCHEMBL8274147 | 0.74 | L3MBTL1 (0.39) | LMNAPIP4K2CL3MBTL1CCR1CCR8 | |
| SCHEMBL12426313 | 0.74 | KDM4E (0.44) | LMNAL3MBTL1CCR1CCR8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703797-B2 | Condensed ring pyridine compounds as subtype-selective modulators of sphingosine-1-phosphate-2 (S1P2) receptors | ALLERGAN, INC. (US) | 2014-04-22 | — | — | US | disclosed |
| US-20130296361-A1 | Condensed Ring Pyridine Compounds As Subtype-Selective Modulators Of Sphingosine-1-Phosphate-2 (S1P2) Receptors | ALLERGAN, INC. | 2013-11-07 | — | — | US | disclosed |
| US-8507682-B2 | Condensed ring pyridine compounds as subtype-selective modulators of sphingosine-1-phosphate-2 (S1P2) receptors | ALLERGAN, INC. (US) | 2013-08-13 | — | — | US | disclosed |
| US-20120208840-A1 | Condensed Ring Pyridine Compounds As Subtype-Selective Modulators Of Sphingosine-1-Phosphate-2 (S1P2) Receptors | ALLERGAN, INC. (US) | 2012-08-16 | — | — | US | disclosed |
| EP-2483245-A1 | CONDENSED RING PYRIDINE COMPOUNDS AS SUBTYPE-SELECTIVE MODULATORS OF SPHINGOSINE-1-PHOSPHATE-2 (S1P2) RECEPTORS | Allergan, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041287-A1 | CONDENSED RING PYRIDINE COMPOUNDS AS SUBTYPE-SELECTIVE MODULATORS OF SPHINGOSINE-1-PHOSPHATE-2 (S1P2) RECEPTORS | ALLERGAN, INC. (US) | 2011-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130296361-A1 | Condensed Ring Pyridine Compounds As Subtype-Selective Modulators Of Sphingosine-1-Phosphate-2 (S1P2) Receptors | S1PR1, S1PR2, S1PR3 | LMNA 1307/4885PIP4K2C 951/4885L3MBTL1 2354/4885 |
| US-20120208840-A1 | Condensed Ring Pyridine Compounds As Subtype-Selective Modulators Of Sphingosine-1-Phosphate-2 (S1P2) Receptors | S1PR1, S1PR2, S1PR3 | LMNA 1307/4885PIP4K2C 951/4885L3MBTL1 2354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.