Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | EP300 | Q09472 | 1/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.47 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.46 |
| ▸ | PRCP | P42785 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3518014 | 0.95 | AKR1C1 (0.61) | SMN1; SMN2TSHRAKR1C1HDAC4SIGMAR1 | |
| SCHEMBL5379328 | 0.92 | TSHR (0.63) | SMN1; SMN2TSHRAKR1C1HDAC4SIGMAR1 | |
| SCHEMBL24203744 | 0.84 | SMN1; SMN2 (0.56) | SMN1; SMN2TSHRAKR1C1HDAC4SIGMAR1 | |
| SCHEMBL5356989 | 0.84 | OPRM1 (0.57) | SMN1; SMN2TSHRAKR1C1HDAC4SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7624556 | 0.83 | OPRM1 (0.56) | SMN1; SMN2TSHRAKR1C1SIGMAR1OPRM1 | |
| SCHEMBL15776154 | 0.81 | AKR1C1 (0.53) | TSHRAKR1C1SIGMAR1NCOA1PRCP | |
| SCHEMBL5365441 | 0.80 | HSD11B1 (0.62) | SMN1; SMN2TSHRMEN1KMT2AHSD11B1 | |
| SCHEMBL17222248 | 0.79 | TSHR (0.50) | SMN1; SMN2TSHRAKR1C1HDAC4SIGMAR1 | |
| SCHEMBL17222251 | 0.79 | TSHR (0.50) | SMN1; SMN2TSHRAKR1C1HDAC4SIGMAR1 | |
| SCHEMBL12928712 | 0.79 | AKR1C1 (0.64) | SMN1; SMN2AKR1C1HDAC4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928861-A1 | AMINOCYCLOBUTANE DERIVATIVES, METHOD FOR PREPARING SAME AND THE USE THEREOF AS DRUGS | Pierre Fabre Médicament (FR) | 2015-10-14 | — | — | EP | claimed |
| WO-2014086825-A1 | AMINOCYCLOBUTANE DERIVATIVES, METHOD FOR PREPARING SAME AND THE USE THEREOF AS DRUGS | PIERRE FABRE MEDICAMENT (FR) | 2014-06-12 | — | — | WO | claimed |
| EP-2928861-A1 | AMINOCYCLOBUTANE DERIVATIVES, METHOD FOR PREPARING SAME AND THE USE THEREOF AS DRUGS | Pierre Fabre Médicament (FR) | 2015-10-14 | — | — | EP | disclosed |
| WO-2014086825-A1 | AMINOCYCLOBUTANE DERIVATIVES, METHOD FOR PREPARING SAME AND THE USE THEREOF AS DRUGS | PIERRE FABRE MEDICAMENT (FR) | 2014-06-12 | — | — | WO | disclosed |