Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | GUSB | P08236 | 2/20 | 0.47 |
| ▸ | TNKS | O95271 | 4/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.47 |
| ▸ | FBP1 | P09467 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775766 | 0.87 | PARP1 (0.63) | PARP1ALDH1A1TDP1TNKSTNKS2 | |
| SCHEMBL15775461 | 0.87 | PARP1 (0.63) | PARP1ALDH1A1TDP1TNKSTNKS2 | |
| SCHEMBL15776207 | 0.87 | TNKS (0.60) | PARP1ALDH1A1TDP1TNKSTNKS2 | |
| SCHEMBL15775317 | 0.84 | PARP1 (0.65) | PARP1ALDH1A1TNKSTNKS2FBP1 | |
| SCHEMBL15775897 | 0.84 | PARP1 (0.65) | PARP1ALDH1A1TDP1TNKSTNKS2 | |
| SCHEMBL25326973 | 0.82 | LMNA (0.53) | PARP1ALDH1A1TDP1FBP1CYP19A1 | |
| SCHEMBL6647713 | 0.77 | PARP1 (0.62) | PARP1ALDH1A1TDP1GUSBNPC1 | |
| SCHEMBL15775666 | 0.75 | PARP1 (1.00) | PARP1TDP1TNKSTNKS2 | |
| SCHEMBL15775297 | 0.75 | PARP1 (0.67) | PARP1ALDH1A1TNKSTNKS2 | |
| SCHEMBL31014299 | 0.75 | PARP1 (0.67) | PARP1ALDH1A1TNKSTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |