Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | RHEB | Q15382 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12362586 | 0.85 | PPARG (0.40) | MAPTTP53ALDH1A1IRAK4HDAC6 | |
| SCHEMBL14685206 | 0.84 | TP53 (0.43) | MAPTTP53POLBLMNARAB9A | |
| SCHEMBL26115823 | 0.76 | GRM2 (0.43) | TP53ALDH1A1RHEBPOLBHDAC6 | |
| SCHEMBL22894792 | 0.76 | PPARG (0.40) | MAPTTP53RHEBPOLBHDAC6 | |
| SCHEMBL30590774 | 0.76 | GRM2 (0.43) | TP53ALDH1A1RHEBPOLBHDAC6 | |
| SCHEMBL3423633 | 0.69 | PPARG (0.43) | HDAC6PPARGDRD3GRM2NR1H2 | |
| SCHEMBL2320397 | 0.69 | RORC (0.38) | MAPTTP53RHEB | |
| SCHEMBL104281 | 0.68 | HDAC6 (0.61) | MAPTPOLBHDAC6CYP2D6LMNA | |
| Lithium Ion SCHEMBL3423635 | 0.68 | PPARG (0.40) | MAPTHDAC6PPARGDRD3GRM2 | |
| SCHEMBL14685285 | 0.67 | TLR7 (0.41) | MAPTHDAC6PPARGLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2740730-A1 | DIBENZOOXEPIN DERIVATIVE | Kyowa Hakko Kirin Co., Ltd. (JP) | 2014-06-11 | — | — | EP | disclosed |