Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 18/20 | 0.77 |
| ▸ | ESR2 | Q92731 | 10/20 | 0.68 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | EBP | Q15125 | 3/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.67 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.67 |
| ▸ | DRD3 | P35462 | 2/20 | 0.67 |
| ▸ | HTR6 | P50406 | 2/20 | 0.67 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.67 |
| ▸ | ESRRG | P62508 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15788576 | 1.00 | ESR1 (0.77) | ESR1ESR2CYP19A1KMT2AEBP | |
| SCHEMBL23583980 | 0.95 | ESR1 (0.73) | ESR1ESR2CYP19A1KMT2AEBP | |
| SCHEMBL21538260 | 0.95 | ESR1 (0.73) | ESR1ESR2CYP19A1KMT2AEBP | |
| SCHEMBL15788575 | 0.90 | ESR1 (0.63) | ESR1ESR2CYP19A1KMT2AEBP | |
| SCHEMBL10829107 | 0.87 | ESR1 (1.00) | ESR1ESR2CYP19A1KMT2AEBP | |
| SCHEMBL10048291 | 0.87 | ESR1 (1.00) | ESR1ESR2CYP19A1KMT2AEBP | |
| 4-Oh-Enclomiphene SCHEMBL17152123 | 0.86 | ESR1 (0.90) | ESR1ESR2KMT2AEBPKCNH2 | |
| SCHEMBL15788560 | 0.86 | ESR1 (0.90) | ESR1ESR2KMT2AEBPKCNH2 | |
| 4-Oh-Enclomiphene SCHEMBL6768536 | 0.86 | ESR1 (0.90) | ESR1ESR2KMT2AEBPKCNH2 | |
| 4-Oh-Enclomiphene SCHEMBL14680624 | 0.86 | ESR1 (0.90) | ESR1ESR2KMT2AEBPKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140163114-A1 | TRANS-CLOMIPHENE METABOLITES AND USES THEREOF | REPROS THERAPEUTICS INC. (US) | 2014-06-12 | — | — | US | disclosed |
| US-20140163114-A1 | TRANS-CLOMIPHENE METABOLITES AND USES THEREOF | REPROS THERAPEUTICS INC. (US) | 2014-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140163114-A1 | TRANS-CLOMIPHENE METABOLITES AND USES THEREOF | SHBG, CYP19A1, HMGCR | ESR1 111/4885ESR2 30/4885CYP19A1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.