Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 14/20 | 0.63 |
| ▸ | EBP | Q15125 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.61 |
| ▸ | DRD3 | P35462 | 2/20 | 0.61 |
| ▸ | HTR6 | P50406 | 2/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | IDH1 | O75874 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15788576 | 0.90 | ESR1 (0.77) | ESR1EBPKMT2AKCNH2SIGMAR1 | |
| SCHEMBL15788565 | 0.90 | ESR1 (0.77) | ESR1EBPKMT2AKCNH2SIGMAR1 | |
| SCHEMBL23583980 | 0.90 | ESR1 (0.73) | ESR1EBPKMT2AKCNH2SIGMAR1 | |
| SCHEMBL21538260 | 0.90 | ESR1 (0.73) | ESR1EBPKMT2AKCNH2SIGMAR1 | |
| SCHEMBL18872440 | 0.88 | ESR1 (0.81) | ESR1EBPKMT2AKCNH2SIGMAR1 | |
| SCHEMBL5079405 | 0.87 | ESR1 (0.80) | ESR1EBPKMT2AKCNH2SIGMAR1 | |
| SCHEMBL1152821 | 0.87 | ESR1 (0.80) | ESR1EBPKMT2AKCNH2SIGMAR1 | |
| SCHEMBL1152819 | 0.87 | ESR1 (0.80) | ESR1EBPKMT2AKCNH2SIGMAR1 | |
| SCHEMBL14680644 | 0.87 | ESR1 (0.82) | ESR1EBPKMT2AKCNH2SIGMAR1 | |
| SCHEMBL15788563 | 0.84 | ESR1 (0.79) | ESR1EBPKMT2AKCNH2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9981906-B2 | Trans-clomiphene metabolites and uses thereof | REPROS THERAPEUTICS INC. (US) | 2018-05-29 | — | — | US | disclosed |
| US-20140163114-A1 | TRANS-CLOMIPHENE METABOLITES AND USES THEREOF | REPROS THERAPEUTICS INC. (US) | 2014-06-12 | — | — | US | disclosed |
| US-20140163114-A1 | TRANS-CLOMIPHENE METABOLITES AND USES THEREOF | REPROS THERAPEUTICS INC. (US) | 2014-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140163114-A1 | TRANS-CLOMIPHENE METABOLITES AND USES THEREOF | SHBG, CYP19A1, HMGCR | ESR1 111/4885EBP 423/4885KMT2A 665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.