SCHEMBL158148

SCHEMBL158148

Clc1ccc(Br)cc1Cc1cc2ccccc2s1

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 10/20 0.53
CYP2A6 P11509 3/20 0.46
ADRB2 P07550 1/20 0.46
ASIC3 Q9UHC3 1/20 0.46
LOXL2 Q9Y4K0 1/20 0.46
SLC5A1 P13866 7/20 0.43
AGXT P21549 1/20 0.43
ADRA1D P25100 2/20 0.43
IDH1 O75874 1/20 0.39
NR1D1 P20393 1/20 0.38
NR1H3 Q13133 1/20 0.38
CHRM1 P11229 1/20 0.37
ADRA1A P35348 1/20 0.37
SLC6A3 Q01959 1/20 0.37
CTRC Q99895 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL158385 0.84 SLC5A2 (0.39) SLC5A2LOXL2SLC5A1
SCHEMBL154809 0.84 SLC5A2 (0.39) SLC5A2SLC5A1NR1D1NR1H3
SCHEMBL12782043 0.83 CYP2A6 (0.53) SLC5A2CYP2A6ADRB2ASIC3LOXL2
SCHEMBL14278454 0.82 SLC5A2 (0.53) SLC5A2CYP2A6ADRB2ASIC3LOXL2
SCHEMBL154549 0.82 CYP2A6 (0.50) SLC5A2CYP2A6ADRB2ASIC3LOXL2
SCHEMBL155503 0.82 SLC5A2 (0.53) SLC5A2CYP2A6ADRB2ASIC3LOXL2
SCHEMBL13748566 0.82 SLC5A2 (0.53) SLC5A2CYP2A6ADRB2ASIC3LOXL2
SCHEMBL157625 0.82 SLC5A2 (0.38) SLC5A2CYP2A6ADRB2SLC5A1IDH1
SCHEMBL154205 0.82 SLC5A2 (0.40) SLC5A2SLC5A1CHRM1ADRA1ASLC6A3
SCHEMBL154239 0.82 SLC5A2 (0.40) SLC5A2SLC5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3251679-B1 NOVEL COMPOUNDS HAVING INHIBITORY ACTIVITY AGAINST SODIUM-DEPENDANT GLUCOSE TRANSPORTER MITSUBISHI TANABE PHARMA CORP (JP) 2020-12-16 EP disclosed
EP-1651658-B2 NOVEL COMPOUNDS HAVING INHIBITORY ACTIVITY AGAINST SODIUM-DEPENDANT TRANSPORTER MITSUBISHI TANABE PHARMA CORP (JP) 2020-08-12 EP disclosed
US-20180282363-A1 GLUCOPYRANOSIDE COMPOUND MITSUBISHI TANABE PHARMA CORPORATION (JP) 2018-10-04 US disclosed
EP-3251679-A1 NOVEL COMPOUNDS HAVING INHIBITORY ACTIVITY AGAINST SODIUM-DEPENDANT GLUCOSE TRANSPORTER Mitsubishi Tanabe Pharma Corporation (JP) 2017-12-06 EP disclosed
US-20160108078-A1 GLUCOPYRANOSIDE COMPOUND MITSUBISHI TANABE PHARMA CORPORATION (JP) 2016-04-21 US disclosed
EP-2896397-A1 Novel compounds having inhibitory activity against sodium-dependant glucose transporter Mitsubishi Tanabe Pharma Corporation (JP) 2015-07-22 EP disclosed
EP-2514756-B1 NOVEL COMPOUNDS HAVING INHIBITORY ACTIVITY AGAINST SODIUM-DEPENDANT GLUCOSE TRANSPORTER MITSUBISHI TANABE PHARMA CORP (JP) 2014-12-17 EP disclosed
US-20140296506-A1 GLUCOPYRANOSIDE COMPOUND MITSUBISHI TANABE PHARMA CORPORATION (JP) 2014-10-02 US disclosed
US-8785403-B2 Glucopyranoside compound MITSUBISHI TANABE PHARMA CORPORATION (JP) 2014-07-22 US disclosed
CN-103214471-A Novel compound MITSUBISHI TANABE PHARMA CORP 2013-07-24 CN disclosed
WO-2008013321-A1 NOVEL SGLT INHIBITORS MITSUBISHI TANABE PHARMA CORPORATION (JP) 2008-01-31 WO disclosed
US-20080027014-A1 Novel SGLT inhibitors TANABE SEIYAKU CO., LTD. 2008-01-31 US disclosed
US-20080027014-A1 Novel SGLT inhibitors TANABE SEIYAKU CO., LTD. 2008-01-31 US disclosed
US-20080027014-A1 Novel SGLT inhibitors TANABE SEIYAKU CO., LTD. 2008-01-31 US disclosed
WO-2008013321-A1 NOVEL SGLT INHIBITORS MITSUBISHI TANABE PHARMA CORPORATION (JP) 2008-01-31 WO disclosed
EP-1845095-A1 1-THIO-D-GLUCITOL DERIVATIVES TAISHO PHARMACEUTICAL CO., LTD (JP) 2007-10-17 EP disclosed
CN-1829729-A Novel compounds TANABE SEIYAKU CO (JP) 2006-09-06 CN disclosed
EP-1651658-A1 NOVEL COMPOUNDS HAVING INHIBITORY ACTIVITY AGAINST SODIUM-DEPENDANT TRANSPORTER TANABE SEIYAKU CO., LTD. (JP) 2006-05-03 EP disclosed
US-20050233988-A1 Novel compounds TANABE SEIYAKU CO., LTD. (JP) 2005-10-20 US disclosed
WO-2005012326-A1 NOVEL COMPOUNDS HAVING INHIBITORY ACTIVITY AGAINST SODIUM-DEPENDANT TRANSPORTER TANABE SEIYAKU CO., LTD. (JP) 2005-02-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050233988-A1 Novel compounds CYP1B1, CYP4B1, CYP2B6 SLC5A2 472/4885CYP2A6 48/4885ADRB2 549/4885
US-20080027014-A1 Novel SGLT inhibitors SLC5A1, SLC5A2, SLC10A1 SLC5A2 2/4885CYP2A6 1061/4885ADRB2 770/4885
US-20180282363-A1 GLUCOPYRANOSIDE COMPOUND UGGT1, B3GAT3, FUT6 SLC5A2 5/4885CYP2A6 192/4885ADRB2 890/4885
US-20160108078-A1 GLUCOPYRANOSIDE COMPOUND UGGT1, B3GAT3, FUT6 SLC5A2 5/4885CYP2A6 192/4885ADRB2 890/4885
US-20140296506-A1 GLUCOPYRANOSIDE COMPOUND UGGT1, B3GAT3, FUT6 SLC5A2 5/4885CYP2A6 192/4885ADRB2 890/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.