Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 11/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25260635 | 0.89 | NOTUM (0.42) | GRM5NOTUMCYP3A4HTR1AHTR2A | |
| SCHEMBL5015153 | 0.84 | GRM5 (0.50) | GRM5MEN1KMT2A | |
| SCHEMBL1581839 | 0.84 | GRM5 (0.40) | GRM5MGLL | |
| SCHEMBL1581943 | 0.83 | FFAR1 (0.46) | GRM5NOTUMMGLLMEN1KMT2A | |
| SCHEMBL21258034 | 0.81 | KCNH2 (0.47) | GRM5 | |
| SCHEMBL1581531 | 0.78 | NPC1 (0.43) | GRM5 | |
| SCHEMBL5442730 | 0.78 | FAAH (0.53) | GRM5CYP3A4MEN1KMT2A | |
| SCHEMBL4661655 | 0.76 | GRM5 (0.43) | GRM5NOTUMCYP3A4HTR1AHTR2A | |
| SCHEMBL4660532 | 0.76 | GRM5 (0.43) | GRM5NOTUMCYP3A4HTR1AHTR2A | |
| SCHEMBL27655173 | 0.75 | GRM5 (0.40) | GRM5CYP3A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720872-B1 | ARYL AND HETEROARYL-PIPERIDINECARBOXYLATE DERIVATIVES, THE PREPARATION AND THE USE THEREOF IN THE FORM OF FAAH ENZYME INHIBITORS | SANOFI AVENTIS (FR) | 2011-04-20 | — | — | EP | disclosed |
| EP-1720872-A1 | ARYL AND HETEROARYL-PIPERIDINECARBOXYLATE DERIVATIVES, THE PREPARATION AND THE USE THEREOF IN THE FORM OF FAAH ENZYME INHIBITORS | Sanofi-Aventis (FR) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005090347-A1 | ARYL AND HETEROARYL-PIPERIDINECARBOXYLATE DERIVATIVES, THE PREPARATION AND THE USE THEREOF IN THE FORM OF FAAH ENZYME INHIBITORS | SANOFI-AVENTIS (FR) | 2005-09-29 | — | — | WO | disclosed |