Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13118743 | 0.87 | GRM5 (0.48) | GRM5FFAR1FFAR4PTGESSCN9A | |
| SCHEMBL1581839 | 0.87 | GRM5 (0.40) | GRM5PTGESSCN9ASMN1; SMN2MAPK1 | |
| SCHEMBL1581943 | 0.86 | FFAR1 (0.46) | GRM5FFAR1FFAR4MEN1MAPT | |
| SCHEMBL1581531 | 0.84 | NPC1 (0.43) | GRM5FFAR1FFAR4LMNARAB9A | |
| SCHEMBL1581685 | 0.84 | GRM5 (0.43) | GRM5MEN1KMT2A | |
| SCHEMBL21722921 | 0.80 | RAB9A (0.43) | FFAR1LMNARAB9AMEN1KMT2A | |
| SCHEMBL1198456 | 0.80 | GPR119 (0.61) | KDM4EMEN1KMT2A | |
| SCHEMBL21497617 | 0.79 | SMN1; SMN2 (0.64) | RAB9AMEN1NPC1KMT2ASMN1; SMN2 | |
| SCHEMBL1581175 | 0.78 | KDM4E (0.39) | KDM4EMEN1KMT2A | |
| SCHEMBL2565461 | 0.78 | APP (0.52) | GRM5FFAR1FFAR4PTGESLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984331-A1 | PYRROLIDINE DERIVATIVES AS ERK INHIBITORS | SCHERING CORPORATION (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007097937-A1 | PYRROLIDINE DERIVATIVES AS ERK INHIBITORS | SCHERING CORPORATION (US) | 2007-08-30 | — | — | WO | disclosed |