Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.47 |
| ▸ | USP5 | P45974 | 2/20 | 0.45 |
| ▸ | USP16 | Q9Y5T5 | 2/20 | 0.45 |
| ▸ | USP3 | Q9Y6I4 | 2/20 | 0.45 |
| ▸ | ISG15 | P05161 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | BRAP | Q7Z569 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15820023 | 0.89 | PDE10A (0.44) | HDAC6PDE10ANQO2MEN1KMT2A | |
| SCHEMBL15819077 | 0.89 | NQO2 (0.43) | PDE7AHDAC6USP5USP16USP3 | |
| SCHEMBL15818365 | 0.89 | HDAC6 (0.45) | HDAC6PDE10ANQO2HTR7 | |
| SCHEMBL15818308 | 0.87 | PIK3R2 (0.41) | PDE10ANQO2LMNAGAAHPGD | |
| SCHEMBL12471702 | 0.87 | LMNA (0.44) | NQO2LMNAGAAHPGDMEN1 | |
| SCHEMBL15818965 | 0.86 | PDE10A (0.42) | PDE10ANQO2MEN1KMT2AHTR7 | |
| SCHEMBL15818336 | 0.85 | PDE10A (0.52) | PDE10ALMNAGAAHPGDMEN1 | |
| SCHEMBL15818772 | 0.84 | NQO2 (0.43) | HDAC6PDE10ANQO2LMNAHPGD | |
| SCHEMBL15819885 | 0.84 | LMNA (0.39) | HDAC6PDE10ANQO2LMNAGAA | |
| SCHEMBL15818924 | 0.84 | HDAC6 (0.40) | PDE7AHDAC6USP5USP16USP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2941426-A1 | SUBSTITUTED PYRIMIDINE AMINOALKYL-QUINAZOLONES AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | Gilead Calistoga LLC (US) | 2015-11-11 | — | — | EP | disclosed |
| EP-2935246-A1 | ISOQUINOLINONE OR QUINAZOLINONE PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | Gilead Calistoga LLC (US) | 2015-10-28 | — | — | EP | disclosed |
| WO-2014100767-A1 | ISOQUINOLINONE OR QUINAZOLINONE PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD CALISTOGA LLC (US) | 2014-06-26 | — | — | WO | disclosed |
| WO-2014100765-A1 | SUBSTITUTED PYRIMIDINE AMINOALKYL-QUINAZOLONES AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD CALISTOGA LLC (US) | 2014-06-26 | — | — | WO | disclosed |