Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Buprenorphine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 known ✓ | P41145 | 14/20 | 1.00 |
| ▸ | OPRM1 known ✓ | P35372 | 9/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 10/20 | 1.00 |
| ▸ | OPRL1 | P41146 | 5/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Buprenorphine SCHEMBL24437359 | 1.00 | OPRK1 (1.00) | OPRK1OPRD1OPRM1OPRL1KCNH2 | |
| Buprenorphine SCHEMBL24145260 | 1.00 | OPRK1 (1.00) | OPRK1OPRD1OPRM1OPRL1KCNH2 | |
| Buprenorphine SCHEMBL24145376 | 1.00 | OPRK1 (1.00) | OPRK1OPRD1OPRM1OPRL1KCNH2 | |
| Buprenorphine SCHEMBL24846187 | 1.00 | OPRK1 (1.00) | OPRK1OPRD1OPRM1OPRL1KCNH2 | |
| Buprenorphine SCHEMBL24437360 | 1.00 | OPRK1 (1.00) | OPRK1OPRD1OPRM1OPRL1KCNH2 | |
| Buprenorphine SCHEMBL23647314 | 1.00 | OPRK1 (1.00) | OPRK1OPRD1OPRM1OPRL1KCNH2 | |
| Buprenorphine SCHEMBL24145377 | 1.00 | OPRK1 (1.00) | OPRK1OPRD1OPRM1OPRL1KCNH2 | |
| Buprenorphine SCHEMBL24171581 | 1.00 | OPRK1 (1.00) | OPRK1OPRD1OPRM1OPRL1KCNH2 | |
| Buprenorphine SCHEMBL23629525 | 1.00 | OPRK1 (1.00) | OPRK1OPRD1OPRM1OPRL1KCNH2 | |
| Buprenorphine SCHEMBL24145658 | 1.00 | OPRK1 (1.00) | OPRK1OPRD1OPRM1OPRL1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 58664 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| EP-4747639-A2 | BETA-GALACTOSIDASE ENZYME-BASED IMMUNOASSAY | Abbott Diagnostics Scarborough, Inc. (US) | 2026-05-27 | — | — | EP | claimed |
| CN-122075410-A | Dry powder composition for intranasal delivery | — | 2026-05-26 | — | — | CN | claimed |
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| CN-121588023-B | Soluble microneedle | ZHONGKE WEIZHEN (BEIJING) TECHNOLOGY Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| US-20260141998-A1 | METHOD FOR TRACKING, VERIFYING, AND AUTHENTICATING MULTI-STAGE CHAIN OF CUSTODY | Courtfact, LLC (US) | 2026-05-21 | — | — | US | claimed |
| US-12622904-B2 | Buprenorphine dosing regimens | INDIVIOR UK LIMITED (GB) | 2026-05-12 | — | — | US | claimed |
| US-20260125725-A1 | Compositions And Methods For Making Benzylisoquinoline Alkaloids, Morphinan Alkaloids, Thebaine, And Derivatives Thereof | ANTHEIA INC (US) | 2026-05-07 | — | — | US | claimed |
| EP-4734974-A1 | CANNABINOID COMPOSITION FOR USE IN THE TREATMENT OF PAIN AND/OR INFLAMMATION | Mabewo Phytopharm AG (CH) | 2026-05-06 | — | — | EP | claimed |
| EP-4255391-B1 | LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION | METRIOPHARM AG (CH) | 2026-05-06 | — | — | EP | claimed |
| EP-0170090-A1 | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, intermediates thereto, and processes | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1986-02-05 | — | — | EP | claimed |
| EP-0144243-A1 | Analgesic compositions | RECKITT AND COLMAN PRODUCTS LIMITED (GB) | 1985-06-12 | — | — | EP | claimed |
| US-4486436-A | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same | ANALGESIC ASSOCIATES (US) | 1984-12-04 | — | — | US | claimed |
| US-4473640-A | OF DRUG-GLUCURONIC ACID COMPLEXES | COMBIE JOAN D | 1984-09-25 | — | — | US | claimed |
| US-4464378-A | Method of administering narcotic antagonists and analgesics and novel dosage forms containing same | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 1984-08-07 | — | — | US | claimed |
| US-4464376-A | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same | RICHARDSON-VICKS, INC. (US) | 1984-08-07 | — | — | US | claimed |
| EP-0077393-A1 | NOVEL METHOD OF ADMINISTERING NARCOTIC ANTAGONISTS AND ANALGESICS AND NOVEL DOSAGE FORMS CONTAINING SAME | The University of Kentucky Research Foundation (US) | 1983-04-27 | — | — | EP | claimed |
| EP-0069600-A2 | Pharmaceutical compositions | RECKITT AND COLMAN PRODUCTS LIMITED (GB) | 1983-01-12 | — | — | EP | claimed |
| WO-1982003768-A1 | NOVEL METHOD OF ADMINISTERING NARCOTIC ANTAGONISTS AND ANALGESICS AND NOVEL DOSAGE FORMS CONTAINING SAME | UNIV KENTUCKY (US) | 1982-11-11 | — | — | WO | claimed |
| EP-0046270-A1 | Novel derivatives of bio-affecting phenolic compounds and pharmaceutical composition containing them | INTERx RESEARCH CORPORATION (US) | 1982-02-24 | — | — | EP | claimed |