SCHEMBL15822243

SCHEMBL15822243

CCOC1=CC(=O)CC(CC(C)SC)C1

nearest known ligand 0.38

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.38
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7383326 0.70 ACHE (0.37) MAPT
SCHEMBL17472261 0.68 MEN1 (0.33) MAPT
SCHEMBL15821964 0.68 MAPT (0.68) MAPTTSHR
SCHEMBL10773455 0.67 MAPT (0.41) MAPTTSHR
SCHEMBL17472262 0.65 LMNA (0.36) TSHR
SCHEMBL1021859 0.61
SCHEMBL6518239 0.61 SMN1; SMN2 (0.55) MAPT
SCHEMBL9218116 0.61 BRD4 (0.32)
SCHEMBL15839544 0.60 MAPT (0.35) MAPT
SCHEMBL2622353 0.60 MEN1 (0.41) MAPTTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10696686-B2 Herbicidally active (alkynyl-phenyl)-substituted cyclic dione compounds and derivatives thereof SYNGENTA LIMITED (GB) 2020-06-30 US disclosed
EP-3004043-B1 HERBICIDALLY ACTIVE (ALKYNYL-PHENYL)-SUBSTITUTED CYCLIC DIONE COMPOUNDS AND DERIVATIVES THEREOF SYNGENTA LTD (GB) 2018-01-31 EP disclosed
EP-2935230-B1 HERBICIDALLY ACTIVE CYCLIC DIONE COMPOUNDS, OR DERIVATIVES THEREOF, SUBSTITUTED BY A PHENYL WHICH HAS AN ALKYNYL-CONTAINING SUBSTITUENT SYNGENTA LTD (GB) 2018-01-17 EP disclosed
US-9615577-B2 Herbicidally active cyclic dione compounds, or derivatives therefor, substituted by a phenyl which has an alkynyl-containing substituent SYNGENTA LIMITED (GB) 2017-04-11 US disclosed
US-20160207934-A1 Herbicidally active (alkynyl-phenyl)-substituted cyclic dione compounds and derivatives thereof SYNGENTA LIMITED (GB) 2016-07-21 US disclosed
EP-3004043-A1 HERBICIDALLY ACTIVE (ALKYNYL-PHENYL)-SUBSTITUTED CYCLIC DIONE COMPOUNDS AND DERIVATIVES THEREOF Syngenta Limited (GB) 2016-04-13 EP disclosed
US-20150342185-A1 HERBICIDALLY ACTIVE CYCLIC DIONE COMPOUNDS, OR DERIVATIVES THEREFOR, SUBSTITUTED BY A PHENYL WHICH HAS AN ALKYNYL-CONTAINING SUBSTITUENT SYNGENTA LIMITED (CH) 2015-12-03 US disclosed
EP-2935230-A2 HERBICIDALLY ACTIVE CYCLIC DIONE COMPOUNDS, OR DERIVATIVES THEREOF, SUBSTITUTED BY A PHENYL WHICH HAS AN ALKYNYL-CONTAINING SUBSTITUENT Syngenta Limited (GB) 2015-10-28 EP disclosed
WO-2014191534-A1 HERBICIDALLY ACTIVE (ALKYNYL-PHENYL)-SUBSTITUTED CYCLIC DIONE COMPOUNDS AND DERIVATIVES THEREOF SYNGENTA LIMITED (GB) 2014-12-04 WO disclosed
WO-2014096289-A2 HERBICIDALLY ACTIVE CYCLIC DIONE COMPOUNDS, OR DERIVATIVES THEREOF, SUBSTITUTED BY A PHENYL WHICH HAS AN ALKYNYL-CONTAINING SUBSTITUENT SYNGENTA LIMITED (GB) 2014-06-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10696686-B2 Herbicidally active (alkynyl-phenyl)-substituted cyclic dione compounds and derivatives thereof DDT, CNPY2, CNPY3 MAPT 2308/4885TSHR 810/4885
US-20160207934-A1 Herbicidally active (alkynyl-phenyl)-substituted cyclic dione compounds and derivatives thereof DDT, CNPY2, CNPY3 MAPT 2308/4885TSHR 810/4885
US-20150342185-A1 HERBICIDALLY ACTIVE CYCLIC DIONE COMPOUNDS, OR DERIVATIVES THEREFOR, SUBSTITUTED BY A PHENYL WHICH HAS AN ALKYNYL-CONTAINING SUBSTITUENT CBR3, WEE1, NOTUM MAPT 4880/4885TSHR 1133/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.