Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | METAP1 | P53582 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | CCR8 | P51685 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.43 |
| ▸ | ULK1 | O75385 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.42 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13184082 | 0.82 | LRRK2 (0.54) | LRRK2PIM1NPC1KDM4EMETAP1 | |
| SCHEMBL5199282 | 0.82 | LRRK2 (0.54) | LRRK2PIM1NPC1KDM4EMETAP1 | |
| SCHEMBL29265627 | 0.79 | LRRK2 (0.51) | LRRK2PIM1NPC1KDM4EMETAP1 | |
| SCHEMBL16068661 | 0.79 | LRRK2 (0.51) | LRRK2PIM1NPC1KDM4EMETAP1 | |
| Bromide SCHEMBL3499178 | 0.78 | LRRK2 (0.50) | LRRK2PIM1NPC1KDM4EMETAP1 | |
| SCHEMBL10921085 | 0.77 | KDM4E (0.45) | LRRK2NPC1KDM4EMETAP1LMNA | |
| SCHEMBL10991873 | 0.77 | LRRK2 (0.49) | LRRK2PIM1NPC1KDM4EMETAP1 | |
| SCHEMBL10915208 | 0.77 | LRRK2 (0.49) | LRRK2PIM1NPC1KDM4EMETAP1 | |
| SCHEMBL19924703 | 0.77 | LRRK2 (0.49) | LRRK2PIM1NPC1KDM4EMETAP1 | |
| SCHEMBL4005629 | 0.74 | ALDH1A1 (0.53) | NPC1KDM4ELMNACYP1A2CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935284-A1 | HETEROCYCLIC NUCLEAR HORMONE RECEPTOR MODULATORS | AbbVie Inc. (US) | 2015-10-28 | — | — | EP | disclosed |
| WO-2014094357-A1 | HETEROCYCLIC NUCLEAR HORMONE RECEPTOR MODULATORS | ABBVIE INC. (US) | 2014-06-26 | — | — | WO | disclosed |