Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 1/20 | 0.61 |
| ▸ | PRMT5 | O14744 | 15/20 | 0.60 |
| ▸ | WDR77 | Q9BQA1 | 14/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22527575 | 1.00 | CARM1 (0.61) | CARM1PRMT5WDR77LMNAHTT | |
| SCHEMBL30019323 | 0.86 | CARM1 (0.74) | CARM1PRMT5WDR77LMNAHTT | |
| SCHEMBL30304699 | 0.83 | CARM1 (0.66) | CARM1PRMT5WDR77LMNAHTT | |
| SCHEMBL17813632 | 0.81 | CARM1 (0.68) | CARM1PRMT5WDR77LMNAHTT | |
| SCHEMBL9476995 | 0.80 | CARM1 (0.67) | CARM1PRMT5WDR77LMNAHTT | |
| SCHEMBL20042490 | 0.80 | CARM1 (0.71) | CARM1PRMT5WDR77LMNAHTT | |
| SCHEMBL29374314 | 0.80 | CARM1 (0.67) | CARM1PRMT5WDR77LMNAHTT | |
| SCHEMBL13875133 | 0.80 | CARM1 (0.71) | CARM1PRMT5WDR77LMNAHTT | |
| SCHEMBL15823999 | 0.80 | CARM1 (0.67) | CARM1PRMT5WDR77LMNAHTT | |
| SCHEMBL28823752 | 0.80 | CARM1 (0.72) | CARM1PRMT5WDR77LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200325128-A1 | COMPOUNDS USEFUL IN THE TREATMENT OR PREVENTION OF A PRMT5-MEDIATED DISORDER | Argonaut Therapeutics Limited (GB) | 2020-10-15 | — | — | US | disclosed |
| EP-2935241-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2015-10-28 | — | — | EP | disclosed |
| WO-2014100716-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200325128-A1 | COMPOUNDS USEFUL IN THE TREATMENT OR PREVENTION OF A PRMT5-MEDIATED DISORDER | PRMT5, PRMT6, PRMT1 | CARM1 16/4885PRMT5 1/4885WDR77 213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.