Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.71 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.36 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15825796 | 0.83 | EGFR (1.00) | EGFRPIK3CDPIK3CAFGFR4TDO2 | |
| SCHEMBL9776814 | 0.73 | EGFR (0.55) | EGFRPIK3CDPIK3CAFGFR4AR | |
| SCHEMBL30918007 | 0.73 | EGFR (0.55) | EGFRPIK3CDPIK3CAFGFR4AR | |
| SCHEMBL17376120 | 0.72 | NTSR1 (0.48) | EGFRPSMB5 | |
| SCHEMBL28243443 | 0.70 | EGFR (0.70) | EGFRPIK3CDPIK3CAFGFR4 | |
| SCHEMBL9971309 | 0.70 | EGFR (0.51) | EGFRPIK3CDPIK3CAFGFR4AR | |
| SCHEMBL29985188 | 0.70 | EGFR (0.60) | EGFRPIK3CDPIK3CAFGFR4AR | |
| SCHEMBL1771905 | 0.70 | EGFR (0.60) | EGFRPIK3CDPIK3CAFGFR4AR | |
| SCHEMBL3098892 | 0.69 | EGFR (0.57) | EGFRPIK3CDPIK3CAFGFR4AR | |
| SCHEMBL8644295 | 0.69 | PIK3CA (0.73) | EGFRPIK3CDPIK3CAFGFR4AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2938608-A1 | SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1 | Sanford-Burnham Medical Research Institute (US) | 2015-11-04 | — | — | EP | disclosed |
| WO-2014100501-A1 | SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1 | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2014-06-26 | — | — | WO | disclosed |