Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | HBB | P68871 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23662296 | 0.91 | BRD4 (0.52) | BRD4LMNAPKMGABRA1GABRA5 | |
| SCHEMBL15825941 | 0.88 | BRD4 (0.47) | BRD4LRRK2LMNAPKMGABRA1 | |
| SCHEMBL15825879 | 0.87 | BRD4 (0.47) | BRD4LRRK2LMNAPKMGABRA1 | |
| SCHEMBL16371457 | 0.81 | BRD4 (0.42) | BRD4LMNAPKMGABRA1GABRA5 | |
| SCHEMBL16385133 | 0.77 | LRRK2 (0.34) | BRD4LRRK2BACE1CYP3A4CYP2C9 | |
| SCHEMBL21261331 | 0.77 | BRD4 (0.36) | BRD4BACE1 | |
| SCHEMBL21261405 | 0.77 | BRD4 (0.36) | BRD4BACE1 | |
| SCHEMBL17841098 | 0.76 | FPR2 (0.44) | BRD4BACE1MAPTTP53KDM4E | |
| SCHEMBL15826635 | 0.76 | BRD4 (0.48) | BRD4 | |
| SCHEMBL17373268 | 0.76 | BRD4 (0.39) | BRD4LRRK2MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3019493-B1 | MODIFIED BET-PROTEIN INHIBITING DIHYDROCHINOXALINONES AND DIHYDROPYRIDOPYRAZINONES | Bayer Pharma AG (DE) | 2017-06-14 | — | — | EP | disclosed |
| US-20160176867-A1 | MODIFIED BET-PROTEIN-INHIBITING DIHYDROQUINOXALINONES AND DIHYDROPYRIDOPYRAZINONES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-06-23 | — | — | US | disclosed |
| US-20160176867-A1 | MODIFIED BET-PROTEIN-INHIBITING DIHYDROQUINOXALINONES AND DIHYDROPYRIDOPYRAZINONES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-06-23 | — | — | US | disclosed |
| US-20150344444-A1 | BET-PROTEIN-INHIBITING DIHYDROXYQUINOXALINONES | Bayer Pharma AG (DE) | 2015-12-03 | — | — | US | disclosed |
| US-20150344444-A1 | BET-PROTEIN-INHIBITING DIHYDROXYQUINOXALINONES | Bayer Pharma AG (DE) | 2015-12-03 | — | — | US | disclosed |
| EP-2935261-A1 | BET-PROTEIN-INHIBITING DIHYDROQUINOXALINONES | Bayer Pharma Aktiengesellschaft (DE) | 2015-10-28 | — | — | EP | disclosed |
| WO-2014095775-A1 | BET-PROTEIN-INHIBITING DIHYDROQUINOXALINONES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-06-26 | — | — | WO | disclosed |
| WO-2014095775-A1 | BET-PROTEIN-INHIBITING DIHYDROQUINOXALINONES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150344444-A1 | BET-PROTEIN-INHIBITING DIHYDROXYQUINOXALINONES | BRD4, BET1, BRDT | BRD4 1/4885LRRK2 533/4885LMNA 979/4885 |
| US-20160176867-A1 | MODIFIED BET-PROTEIN-INHIBITING DIHYDROQUINOXALINONES AND DIHYDROPYRIDOPYRAZINONES | BRD4, BRDT, BET1 | BRD4 1/4885LRRK2 565/4885LMNA 1083/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.