Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | HBB | P68871 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15825879 | 0.99 | BRD4 (0.47) | BRD4LMNAPKMGABRA1GABRA5 | |
| SCHEMBL23662296 | 0.94 | BRD4 (0.52) | BRD4LMNAPKMGABRA1GABRA5 | |
| SCHEMBL15825403 | 0.88 | BRD4 (0.45) | BRD4LMNAPKMGABRA1GABRA5 | |
| SCHEMBL16371457 | 0.84 | BRD4 (0.42) | BRD4LMNAPKMGABRA1GABRA5 | |
| SCHEMBL17841098 | 0.79 | FPR2 (0.44) | BRD4MAPTTP53KDM4EALDH1A1 | |
| SCHEMBL7170207 | 0.78 | BRD4 (0.52) | BRD4KMT2AMEN1MAPTTP53 | |
| SCHEMBL21651800 | 0.78 | OPRL1 (0.54) | BRD4LMNAKMT2AMEN1MAPT | |
| SCHEMBL21253052 | 0.75 | HTR2A (0.38) | BRD4LMNAPKMOPRL1 | |
| SCHEMBL15825875 | 0.74 | BRD4 (0.57) | BRD4 | |
| SCHEMBL18064421 | 0.74 | BRD4 (0.41) | BRD4LMNAKMT2AMEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150344444-A1 | BET-PROTEIN-INHIBITING DIHYDROXYQUINOXALINONES | Bayer Pharma AG (DE) | 2015-12-03 | — | — | US | disclosed |
| US-20150344444-A1 | BET-PROTEIN-INHIBITING DIHYDROXYQUINOXALINONES | Bayer Pharma AG (DE) | 2015-12-03 | — | — | US | disclosed |
| EP-2935261-A1 | BET-PROTEIN-INHIBITING DIHYDROQUINOXALINONES | Bayer Pharma Aktiengesellschaft (DE) | 2015-10-28 | — | — | EP | disclosed |
| WO-2014095775-A1 | BET-PROTEIN-INHIBITING DIHYDROQUINOXALINONES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-06-26 | — | — | WO | disclosed |
| WO-2014095775-A1 | BET-PROTEIN-INHIBITING DIHYDROQUINOXALINONES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150344444-A1 | BET-PROTEIN-INHIBITING DIHYDROXYQUINOXALINONES | BRD4, BET1, BRDT | BRD4 1/4885LMNA 979/4885PKM 3762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.